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Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. Additionally we are shipping EIF5B Antibodies (33) and many more products for this protein.
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eIF5B overexpression promotes maturation of G0-like immature oocytes and causes cell death, an alternative to G0, in serum-starved THP1 cells.
The authors show that the cleavage of initiation factor eIF5B during enteroviral infection, along with the viral internal ribosome entry site, plays a role in mediating viral translation under conditions that are nonpermissive for host cell translation.
determination of binding site on eukaryotic initiation factor (show EIF4G1 Proteins) 1A
Transfected nuclear factor 2 trans activates the IF2 promoter in a cell line.
binding of eIF5B might induce conformational changes in both subunits, with ribosomal segments wrapping around the factor
3Cpro-mediated cleavage of eIF5B may thus play an accessory role in the shutoff of translation that occurs in enterovirus-infected cells.
eIF5B, the homologue of bacterial IF2, is a GTPase (show RACGAP1 Proteins) implicated in joining the ribosomal subunits.
Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately.
initiation of translation factor 2
, eukaryotic translation initiation factor 5B
, translation initiation factor IF-2
, translation initiation factor IF2
, annexin V-binding protein ABP-7