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anti-Eural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) Antibodies

NEDD4L encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. Additionally we are shipping Eural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NEDD4L 23327 Q96PU5
NEDD4L 291553  
NEDD4L 83814  
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Top anti-Eural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like Antibodies at antibodies-online.com

Showing 10 out of 58 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-NEDD4L Antibody Titration: 0.2-1 ug/mlELISA Titer: 1... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of NEDD4L Antibody (Center) in mouse brain tissu... 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Mouse Rabbit Un-conjugated WB NEDD4L Antibody (Center)  western blot analysis in mouse brain tissue ... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB NEDD4L antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details
Cow Rabbit Alexa Fluor 594 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Mouse Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details
Mouse Rabbit APC ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 14 Days
$369.79
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$379.50
Details

NEDD4L Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , , ,
,
Rat (Rattus) , , , ,

Mouse (Murine) , , , ,

Top referenced anti-Eural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like Antibodies

  1. Human Polyclonal NEDD4L Primary Antibody for EIA, WB - ABIN953641 : Zhou, Kabra, Olson, Piper, Snyder: Hrs controls sorting of the epithelial Na+ channel between endosomal degradation and recycling pathways. in The Journal of biological chemistry 2010 (PubMed)
    Show all 3 references for ABIN953641

  2. Chicken Polyclonal NEDD4L Primary Antibody for WB - ABIN2774731 : Raikwar, Thomas: Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel. in American journal of physiology. Renal physiology 2008 (PubMed)

More Antibodies against Eural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like Interaction Partners

Human Eural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) interaction partners

  1. Propose regulation of placental SNAT2 (show SLC38A2 Antibodies)/LAT1 (show LAT Antibodies) ubiquitination by mTORC1 and Nedd4-2.

  2. Overexpression of Nedd4-2 enhanced hOAT4 (show SLC22A9 Antibodies) ubiquitination, and inhibited hOAT4 (show SLC22A9 Antibodies) transport activity.

  3. Our results suggest that three screened NEDD4-2 variants do not play a leading role in the pathogenesis of photosensitive epilepsy in the Turkish population.

  4. The mechanisms of activation and degradation of the NEDD4L:the transition from the closed to the active form is regulated by a competition of inositol 1,4,5-trisphosphate and Ca2 (show CA2 Antibodies)+.

  5. Data show that membrane protein Ndfip1 recruits E3 ubiquitin (Ub) ligase Nedd4-2 to the Golgi to target ether-a-go-go-related gene (hERG) channel for degradation while membrane protein Ndfip2 also mediates Nedd4-2 interaction with hERG in the Golgi.

  6. Proteomics analysis of EV71-infected cells reveals the involvement of host protein NEDD4L in EV71 replication.

  7. DDB2 (show DDB2 Antibodies) can bind to the promoter region of NEDD4L and recruit enhancer of zeste homolog 2 (show EZH2 Antibodies) histone methyltransferase to repress NEDD4L transcription by enhancing histone H3 (show HIST3H3 Antibodies) lysine 27 trimethylation at the NEDD4L promoter.

  8. These results suggested that the functional variant of NEDD4L, rs4149601, may be associated with obesity and related phenotypes, and further genetic and functional studies are required to understand its role in the manifestation of obesity.

  9. Genetic variation in NEDD4L may have sex-dependent effects in the development of essential hypertension in Han Chinese

  10. NEDD4L may play a tumor suppressive role in colorectal cancer

Xenopus laevis Eural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) interaction partners

  1. these findings suggest that regulation of Dvl (show DVL2 Antibodies) protein levels by NEDD4L is essential for convergent extension during early Xenopus embryogenesis.

  2. Results suggest a mechanism for epithelial Na+ channel regulation in which AMP (show TMPRSS5 Antibodies)-activated kinase promotes ENaC (show SCNN1A Antibodies)-Nedd4-2 interaction, inhibiting ENaC (show SCNN1A Antibodies) by increasing Nedd4-2-dependent ENaC (show SCNN1A Antibodies) retrieval from the plasma membrane.

  3. results indicate that AMPK (show PRKAA2 Antibodies) inhibits KCNQ1 (show KCNQ1 Antibodies) activity by promoting Nedd4-2-dependent channel ubiquitination and retrieval from the plasma membrane.

  4. This study suggested that Nedd4-regulated PTEN (show PTEN Antibodies) is a key regulator of terminal arborization in vivo.

  5. ENaC-beta (show SCNN1B Antibodies) regulation that occurs through IKKbeta (show IKBKB Antibodies)-dependent Nedd4-2 phosphorylation at a recognized SGK1 (show SGK1 Antibodies) and protein kinase A target site.

Mouse (Murine) Eural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) interaction partners

  1. We identified glutamate (show GRIN1 Antibodies) receptor subunit 1 (GluA1 (show GRIA1 Antibodies)), subunit of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors as a novel substrate of Nedd4-2

  2. The short isoform of the ubiquitin ligase (show RNF123 Antibodies) NEDD4L is a CREB (show CREB1 Antibodies) target gene in hepatocytes.

  3. Nedd4-2-mediated ubiquitination of beta-ENaC (show SCNN1B Antibodies) leading to endocytosis and degradation of apical Na(+) channels is a key feature of hypoxia-induced inhibition of transepithelial alveolar Na(+) transport.

  4. The first physiological evidence for an essential function of Nedd4-2 in regulating voltage-gated sodium channels in the central nervous system.

  5. NEDD4-2 is a potent posttranslational regulator of voltage-gated sodium channels.

  6. loss of NEDD4-2 in adult renal tubules causes a new form of mild, salt-sensitive hypertension without hyperkalemia that is characterized by upregulation of NCC (show SLC12A3 Antibodies), elevation of beta/gammaENaC (show SCNN1G Antibodies), but not alphaENaC (show SCNN1A Antibodies), and a normal Na+/K+ balance

  7. Neural precursor cell-expressed developmentally down-regulated protein 4 (show NEDD4 Antibodies)-2 (Nedd4-2) regulation by 14-3-3 protein (show YWHAE Antibodies) binding at canonical serum and glucocorticoid kinase 1 (SGK1 (show SGK1 Antibodies)) phosphorylation sites.

  8. Dlg3 (show DLG3 Antibodies) exerts a distinct function by recruiting the ubiquitin ligases Nedd4 and Nedd4-2 through its PPxY motifs. These interactions are required for Dlg3 (show DLG3 Antibodies) monoubiquitination, apical membrane recruitment, and tight junction consolidation.

  9. deficiency of Nedd4-2 in the renal tubules upregulated the Na(+)-Cl(-) cotransporter (show SLC12A3 Antibodies)

  10. ubiquitin ligase (show RNF123 Antibodies) Nedd4L can suppress the onset of cystic fibrosis (show S100A8 Antibodies) symptoms by inhibiting ENaC (show SCNN1A Antibodies) in lung epithelia.

Eural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) Antigen Profile

Protein Summary

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with NEDD4L

  • neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase (NEDD4L) antibody
  • NEDD4L (LOC776799) antibody
  • neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase (nedd4l) antibody
  • neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase (Nedd4l) antibody
  • neural precursor cell expressed, developmentally down-regulated gene 4-like (Nedd4l) antibody
  • 1300012C07Rik antibody
  • hNEDD4-2 antibody
  • NEDD4 antibody
  • Nedd4-2 antibody
  • NEDD4.2 antibody
  • Nedd4b antibody
  • RSP5 antibody

Protein level used designations for NEDD4L

E3 ubiquitin-protein ligase NEDD4-like , E3 ubiquitin-protein ligase NEDD4-like protein , ubiquitin-protein ligase Rsp5 , neural precursor cell expressed, developmentally down-regulated 4 , NEDD4.2 , neural precursor cell expressed, developmentally down-regulated gene 4b

GENE ID SPECIES
100054395 Equus caballus
100172429 Pongo abelii
776799 Gallus gallus
23327 Homo sapiens
399396 Xenopus laevis
510003 Bos taurus
291553 Rattus norvegicus
100512083 Sus scrofa
476189 Canis lupus familiaris
83814 Mus musculus
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