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Eural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like Proteins (NEDD4L)

NEDD4L encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. Additionally we are shipping Eural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like Antibodies (57) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NEDD4L 23327 Q96PU5
Rat NEDD4L NEDD4L 291553  
NEDD4L 83814  
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Top Eural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
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NEDD4L Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Eural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) Interaction Partners

Human Eural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) interaction partners

  1. Propose regulation of placental SNAT2 (show SLC38A2 Proteins)/LAT1 (show LAT Proteins) ubiquitination by mTORC1 and Nedd4-2.

  2. Overexpression of Nedd4-2 enhanced hOAT4 (show SLC22A9 Proteins) ubiquitination, and inhibited hOAT4 (show SLC22A9 Proteins) transport activity.

  3. Our results suggest that three screened NEDD4-2 variants do not play a leading role in the pathogenesis of photosensitive epilepsy in the Turkish population.

  4. The mechanisms of activation and degradation of the NEDD4L:the transition from the closed to the active form is regulated by a competition of inositol 1,4,5-trisphosphate and Ca2 (show CA2 Proteins)+.

  5. Data show that membrane protein Ndfip1 recruits E3 ubiquitin (Ub) ligase Nedd4-2 to the Golgi to target ether-a-go-go-related gene (hERG) channel for degradation while membrane protein Ndfip2 also mediates Nedd4-2 interaction with hERG in the Golgi.

  6. Proteomics analysis of EV71-infected cells reveals the involvement of host protein NEDD4L in EV71 replication.

  7. DDB2 (show DDB2 Proteins) can bind to the promoter region of NEDD4L and recruit enhancer of zeste homolog 2 (show EZH2 Proteins) histone methyltransferase to repress NEDD4L transcription by enhancing histone H3 (show HIST3H3 Proteins) lysine 27 trimethylation at the NEDD4L promoter.

  8. These results suggested that the functional variant of NEDD4L, rs4149601, may be associated with obesity and related phenotypes, and further genetic and functional studies are required to understand its role in the manifestation of obesity.

  9. Genetic variation in NEDD4L may have sex-dependent effects in the development of essential hypertension in Han Chinese

  10. NEDD4L may play a tumor suppressive role in colorectal cancer

Xenopus laevis Eural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) interaction partners

  1. these findings suggest that regulation of Dvl (show DVL2 Proteins) protein levels by NEDD4L is essential for convergent extension during early Xenopus embryogenesis.

  2. Results suggest a mechanism for epithelial Na+ channel regulation in which AMP (show TMPRSS5 Proteins)-activated kinase promotes ENaC (show SCNN1A Proteins)-Nedd4-2 interaction, inhibiting ENaC (show SCNN1A Proteins) by increasing Nedd4-2-dependent ENaC (show SCNN1A Proteins) retrieval from the plasma membrane.

  3. results indicate that AMPK (show PRKAA2 Proteins) inhibits KCNQ1 (show KCNQ1 Proteins) activity by promoting Nedd4-2-dependent channel ubiquitination and retrieval from the plasma membrane.

  4. This study suggested that Nedd4-regulated PTEN is a key regulator of terminal arborization in vivo.

  5. ENaC-beta (show SCNN1B Proteins) regulation that occurs through IKKbeta (show IKBKB Proteins)-dependent Nedd4-2 phosphorylation at a recognized SGK1 (show SGK1 Proteins) and protein kinase A target site.

Mouse (Murine) Eural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) interaction partners

  1. These findings elucidate a critical role of Mdm2 (show MDM2 Proteins)-p53 (show TP53 Proteins)-Nedd4-2 signaling underlying the regulation of neural network synchrony and seizure susceptibility.

  2. We identified glutamate (show GRIN1 Proteins) receptor subunit 1 (GluA1 (show GRIA1 Proteins)), subunit of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors as a novel substrate of Nedd4-2

  3. The short isoform of the ubiquitin ligase (show RNF123 Proteins) NEDD4L is a CREB (show CREB1 Proteins) target gene in hepatocytes.

  4. Nedd4-2-mediated ubiquitination of beta-ENaC (show SCNN1B Proteins) leading to endocytosis and degradation of apical Na(+) channels is a key feature of hypoxia-induced inhibition of transepithelial alveolar Na(+) transport.

  5. The first physiological evidence for an essential function of Nedd4-2 in regulating voltage-gated sodium channels in the central nervous system.

  6. NEDD4-2 is a potent posttranslational regulator of voltage-gated sodium channels.

  7. loss of NEDD4-2 in adult renal tubules causes a new form of mild, salt-sensitive hypertension without hyperkalemia that is characterized by upregulation of NCC (show SLC12A3 Proteins), elevation of beta/gammaENaC (show SCNN1G Proteins), but not alphaENaC (show SCNN1A Proteins), and a normal Na+/K+ balance

  8. Neural precursor cell-expressed developmentally down-regulated protein 4 (show NEDD4 Proteins)-2 (Nedd4-2) regulation by 14-3-3 protein (show YWHAE Proteins) binding at canonical serum and glucocorticoid kinase 1 (SGK1 (show SGK1 Proteins)) phosphorylation sites.

  9. Dlg3 (show DLG3 Proteins) exerts a distinct function by recruiting the ubiquitin ligases Nedd4 and Nedd4-2 through its PPxY motifs. These interactions are required for Dlg3 (show DLG3 Proteins) monoubiquitination, apical membrane recruitment, and tight junction consolidation.

  10. deficiency of Nedd4-2 in the renal tubules upregulated the Na(+)-Cl(-) cotransporter (show SLC12A3 Proteins)

Eural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) Protein Profile

Protein Summary

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with NEDD4L

  • neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase (NEDD4L)
  • NEDD4L (LOC776799)
  • neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase (nedd4l)
  • neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase (Nedd4l)
  • neural precursor cell expressed, developmentally down-regulated gene 4-like (Nedd4l)
  • 1300012C07Rik protein
  • hNEDD4-2 protein
  • NEDD4 protein
  • Nedd4-2 protein
  • NEDD4.2 protein
  • Nedd4b protein
  • RSP5 protein

Protein level used designations for NEDD4L

E3 ubiquitin-protein ligase NEDD4-like , E3 ubiquitin-protein ligase NEDD4-like protein , ubiquitin-protein ligase Rsp5 , neural precursor cell expressed, developmentally down-regulated 4 , NEDD4.2 , neural precursor cell expressed, developmentally down-regulated gene 4b

GENE ID SPECIES
100054395 Equus caballus
100172429 Pongo abelii
776799 Gallus gallus
23327 Homo sapiens
399396 Xenopus laevis
510003 Bos taurus
291553 Rattus norvegicus
100512083 Sus scrofa
476189 Canis lupus familiaris
83814 Mus musculus
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