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EWSR1 encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. Additionally we are shipping EWSR1 Proteins (4) and EWSR1 Kits (3) and many more products for this protein.
Showing 10 out of 120 products:
Human Polyclonal EWSR1 Primary Antibody for IF, WB - ABIN658497
Lagirand-Cantaloube, Laud, Lilienbaum, Tirode, Delattre, Auclair, Kryszke: EWS-FLI1 inhibits TNFalpha-induced NFkappaB-dependent transcription in Ewing sarcoma cells. in Biochemical and biophysical research communications 2010
Show all 5 references for ABIN658497
Human Polyclonal EWSR1 Primary Antibody for ELISA, WB - ABIN1451580
Delattre, Zucman, Plougastel, Desmaze, Melot, Peter, Kovar, Joubert, de Jong, Rouleau: Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. in Nature 1992
Show all 2 references for ABIN1451580
Chicken Polyclonal EWSR1 Primary Antibody for WB - ABIN2779045
Brandal, Panagopoulos, Bjerkehagen, Gorunova, Skjeldal, Micci, Heim: Detection of a t(1;22)(q23;q12) translocation leading to an EWSR1-PBX1 fusion gene in a myoepithelioma. in Genes, chromosomes & cancer 2008
Human Polyclonal EWSR1 Primary Antibody for EIA, WB - ABIN453643
Bhagirath, Abe, Nojima, Yoshida: Molecular analysis of a t(11;22) translocation junction in a case of Ewing's sarcoma. in Genes, chromosomes & cancer 1995
Cow (Bovine) Polyclonal EWSR1 Primary Antibody for EIA, IHC (p) - ABIN375098
Toretsky, Erkizan, Levenson, Abaan, Parvin, Cripe, Rice, Lee, Uren: Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A. in Cancer research 2006
EWSR1 is involved in the post-transcriptional regulation of Uvrag (show UVRAG Antibodies) via a miRNA-dependent pathway, resulting in the deregulation of autophagy inhibition.
EWS is essential during the early steps of white adipocyte differentiation, at least in part through its regulation of BMP2 (show BMP2 Antibodies) and BMP4 (show BMP4 Antibodies) expression.
EWS has a role in mitochondrial and cellular energy homeostasis that involves controlling PGC-1alpha (show PPARGC1A Antibodies) protein stability
both Etv1 (show ETV1 Antibodies) and Ewsr1 were necessary for Fgf10 (show FGF10 Antibodies) expression and elongation of the limb bud.
EWS is involved in post-transcriptional regulation of Col4a1 (show COL4A1 Antibodies) and CTGF (show CTGF Antibodies) via a Drosha (show DROSHA Antibodies)-miRNA-dependent pathway.
These results demonstrate that EWS is essential for early brown fat lineage determination.
Forced expression of EWS/ATF1 (show AFT1 Antibodies) resulted in the development of EWS/ATF1 (show AFT1 Antibodies)-dependent sarcomas. Lineage-tracing experiments indicated that neural crest-derived cells were subject to EWS/ATF1 (show AFT1 Antibodies)-driven transformation.
these findings suggest that EWS mediates generation of mature let-7g from pre-let-7g.
EWS is likely to play a significant role in maintaining the functional capacity of stem cells.
Findings suggest that EWS/FLI1 (show FLI1 Antibodies) induces apoptosis, at least partially, through the activation of CASP3 (show CASP3 Antibodies).
Mutation of the EWS gene modulates Sox9 (show SOX9 Antibodies) gene expression essential for chondrocyte differentiation.
Ewsr1 maintains mitotic integrity and proneural cell survival in early zebrafish development
Interaction between EWSR1/FLI1 (show FLI1 Antibodies) and EWSR1 in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.
FUS (show FUS Antibodies) and EWS target genes involved in pathways at the RNA regulatory level
Identify SP1 (show PSG1 Antibodies) and PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling as modulators of EWS/FLI1 (show FLI1 Antibodies) gene expression in tumor cell lines.
Case Reports: 2 girls with primary renal myoepithelial carcinomas with a novel EWSR1-KLF15 fusion.
3'-UTR (show UTS2R Antibodies) poly(T/U) repeat of EWSR1 is altered in microsatellite unstable colorectal cancer.
study investigated EWSR1 status in ovarian hemangiomas; all cases were negative for EWSR1 rearrangement; 2 cases demonstrated additional intact copies of EWSR1 indicating aneusomy 22 or structural abnormality of chromosome 22 resulting in apparent duplication of the EWSR1 gene region
The paper investigates the presence of EWS/FLI-1 (show FLI1 Antibodies) fusion in clinically diagnosed sarcoma belonging to different non-Ewing connective tissue tumors.
Results show that RNA-binding protein EWS binds and regulates CCDC6 (show CCDC6 Antibodies) expression at RNA and protein levels.
KLF17 (show KLF17 Antibodies) is also a rare gene fusion partner to EWSR1-rearranged myoepithelial tumors.
The impairment of EWS-dependent midzone formation via the recruitment of Aurora B (show AURKB Antibodies) is a potential mechanism of Ewing sarcoma development.
These data support epigenetic modulation with HCI2509 as a therapeutic strategy for Ewing sarcoma, and highlight a critical dual role for LSD1 (show KDM1A Antibodies) in the oncogenic transcriptional activity of EWS/ETS (show ETS1 Antibodies) proteins
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11\;22)(q24\;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.
RNA-binding protein EWS
, Ewing sarcoma RNA-binding protein
, Ewing sarcoma breakpoint region 1
, Ewing sarcoma homolog
, Ewings sarcoma EWS-Fli1 (type 1) oncogene