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EWSR1 encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. Additionally we are shipping EWSR1 Antibodies (149) and EWSR1 Proteins (4) and many more products for this protein.
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EWS is normally O-GlcNAc glycosylated in the brain.
glycosylation of EWS protein
EWSR1 is involved in the post-transcriptional regulation of Uvrag via a miRNA-dependent pathway, resulting in the deregulation of autophagy inhibition.
EWS is essential during the early steps of white adipocyte differentiation, at least in part through its regulation of BMP2 (show BMP2 ELISA Kits) and BMP4 (show BMP4 ELISA Kits) expression.
EWS has a role in mitochondrial and cellular energy homeostasis that involves controlling PGC-1alpha (show PPARGC1A ELISA Kits) protein stability
both Etv1 (show ETV1 ELISA Kits) and Ewsr1 were necessary for Fgf10 (show FGF10 ELISA Kits) expression and elongation of the limb bud.
EWS is involved in post-transcriptional regulation of Col4a1 (show COL4A1 ELISA Kits) and CTGF (show CTGF ELISA Kits) via a Drosha (show DROSHA ELISA Kits)-miRNA-dependent pathway.
These results demonstrate that EWS is essential for early brown fat lineage determination.
Forced expression of EWS/ATF1 (show AFT1 ELISA Kits) resulted in the development of EWS/ATF1 (show AFT1 ELISA Kits)-dependent sarcomas. Lineage-tracing experiments indicated that neural crest-derived cells were subject to EWS/ATF1 (show AFT1 ELISA Kits)-driven transformation.
these findings suggest that EWS mediates generation of mature let-7g from pre-let-7g.
Mutation of the EWS gene modulates Sox9 (show SOX9 ELISA Kits) gene expression essential for chondrocyte differentiation.
Ewsr1 maintains mitotic integrity and proneural cell survival in early zebrafish development
Interaction between EWSR1/FLI1 (show FLI1 ELISA Kits) and EWSR1 in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.
EWSR1-related rearrangement was detected extraskeletal myxoid chondrosarcoma
a novel EWSR1/ETS (show ETS1 ELISA Kits) chimeric gene, was identified in a patient diagnosed with refractory AML (show RUNX1 ELISA Kits), suggesting a potential role of leukemogenesis in rare cases of AML (show RUNX1 ELISA Kits). This fusion gene is very likely to exhibit oncogenic potential by interfering with the p53 (show TP53 ELISA Kits)/p21 (show CDKN1A ELISA Kits)-dependent pathway.
LRWD1 is a novel regulator of EWS-FLI1 (show FLI1 ELISA Kits) driven cell proliferation in Ewing sarcoma cells. EWS-FLI1 (show FLI1 ELISA Kits) regulates LRWD1 expression and LRWD1 may contribute to EWS-FLI1 (show FLI1 ELISA Kits) mediated transcriptional repression.
Ewing sarcoma may be susceptible to treatment with epigenetic inhibitors blocking BRD3 (show BRD3 ELISA Kits)/4 activity and the associated pathognomonic EWS-FLT1 (show FLT1 ELISA Kits) transcriptional program.
prevalence of the FUS (show FUS ELISA Kits)-ERG (show ERG ELISA Kits) gene fusion in a large cohort of pathologically and molecularly well characterized small blue round cell tumors, lacking other known gene rearrangements
FUS (show FUS ELISA Kits) and EWS target genes involved in pathways at the RNA regulatory level
Identify SP1 (show PSG1 ELISA Kits) and PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) signaling as modulators of EWS/FLI1 (show FLI1 ELISA Kits) gene expression in tumor cell lines.
Case Reports: 2 girls with primary renal myoepithelial carcinomas with a novel EWSR1-KLF15 (show KLF15 ELISA Kits) fusion.
3'-UTR (show UTS2R ELISA Kits) poly(T/U) repeat of EWSR1 is altered in microsatellite unstable colorectal cancer.
study investigated EWSR1 status in ovarian hemangiomas; all cases were negative for EWSR1 rearrangement; 2 cases demonstrated additional intact copies of EWSR1 indicating aneusomy 22 or structural abnormality of chromosome 22 resulting in apparent duplication of the EWSR1 gene region
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11\;22)(q24\;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.
RNA-binding protein EWS
, Ewing sarcoma RNA-binding protein
, Ewing sarcoma breakpoint region 1
, Ewing sarcoma homolog
, Ewings sarcoma EWS-Fli1 (type 1) oncogene