You are viewing an incomplete version of our website. Please click to reload the website as full version.

Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6-Like 2 Proteins (ERCC6L2)

DNA helicase that acts as an essential component of the spindle assembly checkpoint. Additionally we are shipping ERCC6L2 Antibodies (23) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ERCC6L2 76251 Q6DI94,Q9JIM3
ERCC6L2 54821 Q2NKX8
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top ERCC6L2 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

ERCC6L2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6-Like 2 (ERCC6L2) Interaction Partners

Human Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6-Like 2 (ERCC6L2) interaction partners

  1. PICH and Topo II (show TOP2 Proteins) cooperate to prevent chromosome missegregation events in mitosis.

  2. PICH is a SUMO-interacting protein and a mitotic SUMO substrate.

  3. These observations identify a distinct bone-marrow-failure syndrome due to mutations in ERCC6L2, a gene implicated in DNA repair and mitochondrial function.

  4. PICH binds to BLM and enables BLM localization to anaphase centromeric threads. PICH and BLM unravel centromeric chromatin and keep anaphase DNA threads mostly free of nucleosomes.

  5. the PICH-Plk1 complex plays a critical role in maintaining prometaphase chromosome architecture

  6. the spindle checkpoint failure formerly attributed to the depletion of PICH most likely reflects an off-target effect that causes the lowering of Mad2 (show MAD2L1 Proteins) transcript and protein.

  7. PICH phosphorylation and its ATPase activity are required for mitotic chromosome compaction through the targeting of Plk1 to chromosome arms.

  8. Functional characterization of the mouse Ercc6l (show ERCC6L Proteins) ortholog.

ERCC6L2 Protein Profile

Protein Summary

DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase.

Gene names and symbols associated with ERCC6L2

  • excision repair cross-complementing rodent repair deficiency, complementation group 6 like 2 (Ercc6l2)
  • excision repair cross-complementing rodent repair deficiency, complementation group 6-like (ERCC6L)
  • excision repair cross-complementing rodent repair deficiency, complementation group 6-like 2 (ERCC6L2)
  • 0610007P08Rik protein
  • 1700019D06Rik protein
  • 9330134C04Rik protein
  • C9orf102 protein
  • PICH protein
  • RAD26L protein
  • SR278 protein

Protein level used designations for ERCC6L2

RAD26L hypothetical protein , putative repair and recombination helicase RAD26L , stretch responsive protein 278 , ATP-dependent helicase ERCC6-like , DNA excision repair protein ERCC-6-like , Plk1-interacting checkpoint helicase , SNF2/RAD54 family protein , excision repair cross-complementing rodent repair deficiency complementation group 6 - like , excision repair protein ERCC6-like , tumor antigen BJ-HCC-15 , putative DNA repair and recombination protein RAD26-like

GENE ID SPECIES
76251 Mus musculus
54821 Homo sapiens
375748 Homo sapiens
Selected quality suppliers for ERCC6L2 Proteins (ERCC6L2)
Did you look for something else?