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DNA helicase that acts as an essential component of the spindle assembly checkpoint. Additionally we are shipping ERCC6L2 Antibodies (25) and ERCC6L2 Proteins (3) and many more products for this protein.
Hebo is ubiquitously expressed, localized in the nucleus, and rapidly recruited to DNAdsb's in an NBS1 (show NBN ELISA Kits)-dependent manner.
a novel SUMO-dependent regulation of PICH's function on mitotic centromeres, is reported.
PICH and Topo II (show TOP2 ELISA Kits) cooperate to prevent chromosome missegregation events in mitosis.
PICH is a SUMO-interacting protein and a mitotic SUMO substrate.
These observations identify a distinct bone-marrow-failure syndrome due to mutations in ERCC6L2, a gene implicated in DNA repair and mitochondrial function.
PICH binds to BLM and enables BLM localization to anaphase centromeric threads. PICH and BLM unravel centromeric chromatin and keep anaphase DNA threads mostly free of nucleosomes.
the PICH-Plk1 (show PLK1 ELISA Kits) complex plays a critical role in maintaining prometaphase chromosome architecture
the spindle checkpoint failure formerly attributed to the depletion of PICH most likely reflects an off-target effect that causes the lowering of Mad2 (show MAD2L1 ELISA Kits) transcript and protein.
PICH phosphorylation and its ATPase (show DNAH8 ELISA Kits) activity are required for mitotic chromosome compaction through the targeting of Plk1 (show PLK1 ELISA Kits) to chromosome arms.
Functional characterization of the mouse Ercc6l (show ERCC6L ELISA Kits) ortholog.
DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase.
ATP-dependent helicase ERCC6-like
, DNA excision repair protein ERCC-6-like
, Plk1-interacting checkpoint helicase
, SNF2/RAD54 family protein
, excision repair cross-complementing rodent repair deficiency complementation group 6 - like
, excision repair protein ERCC6-like
, tumor antigen BJ-HCC-15
, RAD26L hypothetical protein
, putative repair and recombination helicase RAD26L
, stretch responsive protein 278
, putative DNA repair and recombination protein RAD26-like
, DNA excision repair protein ERCC-6-like 2