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Exosome Component 4 Proteins (EXOSC4)

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. Additionally we are shipping Exosome Component 4 Antibodies (35) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EXOSC4 54512 Q9NPD3
EXOSC4 109075 Q921I9
Rat EXOSC4 EXOSC4 300045  
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Top Exosome Component 4 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,623.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$498.21
Details

EXOSC4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Exosome Component 4 (EXOSC4) Interaction Partners

Human Exosome Component 4 (EXOSC4) interaction partners

  1. Knock-down of hRrp41p or hRrp4p (show EXOSC2 Proteins) but not PM/Scl-100 (show EXOSC10 Proteins) or PM/Scl-75 (show EXOSC9 Proteins) leads to codepletion of other subunits.

  2. Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase (show PNPT1 Proteins)-like ring.

Exosome Component 4 (EXOSC4) Protein Profile

Protein Summary

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs (By similarity).

Gene names and symbols associated with Exosome Component 4 Proteins (EXOSC4)

  • exosome component 4 (exosc4)
  • exosome component 4 (EXOSC4)
  • exosome component 4 (CC1G_03561)
  • exosome component 4 (Exosc4)
  • 1110039I09Rik protein
  • 1500001N04Rik protein
  • EXOSC4 protein
  • hRrp41p protein
  • p12A protein
  • Rrp41 protein
  • RRP41A protein
  • Rrp41p protein
  • SKI6 protein
  • Ski6p protein
  • zgc:73175 protein

Protein level used designations for Exosome Component 4 Proteins (EXOSC4)

exosome component 4 , exosome complex component RRP41 , exosome complex exonuclease RRP41 , exosome component Rrp41 , ribosomal RNA-processing protein 41 , ribosomal RNA processing protein 41

GENE ID SPECIES
549190 Xenopus (Silurana) tropicalis
700012 Macaca mulatta
740889 Pan troglodytes
6009034 Coprinopsis cinerea okayama7130
393712 Danio rerio
495942 Xenopus laevis
54512 Homo sapiens
482086 Canis lupus familiaris
618292 Bos taurus
109075 Mus musculus
300045 Rattus norvegicus
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