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Exostosin 1 Proteins (EXT1)

EXT1 encodes an endoplasmic reticulum-resident type II transmembrane glycosyltransferase involved in the chain elongation step of heparan sulfate biosynthesis. Additionally we are shipping EXT1 Antibodies (57) and EXT1 Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EXT1 14042 P97464
EXT1 2131 Q16394
Rat EXT1 EXT1 299907  
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Top EXT1 Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 11 to 13 Days
$732.60
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$904.80
Details

EXT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , ,
, ,

More Proteins for Exostosin 1 (EXT1) Interaction Partners

Zebrafish Exostosin 1 (EXT1) interaction partners

  1. the three zebrafish ext1 genes encode proteoglycan (show Vcan Proteins) modifying enzymes and have distinct relationships to somitic Sonic hedgehog (show SHH Proteins) signaling

Mouse (Murine) Exostosin 1 (EXT1) interaction partners

  1. Normal heparin sulfate levels and Ext1 activity in the stromal microenvironment and hematopoietic stem cells are required for the transplant engraftment following non-myeloablative conditioning.

  2. Heterozygous loss of function of EXT1 and EXT2 results in a decreased arteriolar endothelial glycocalyx but improved flow mediated vasodilation.

  3. Ext genes and heparan sulfate are needed to establish and maintain perichondrium's phenotype and border function.

  4. Levels of Ext1 and HPSE (show HPSE Proteins) influence the motility of FBJ osteosarcoma cells.

  5. stromal Ext1-levels modulate tumor cell proliferation and affect the interstitial fluid pressure in a 3-D spheroid model.

  6. The study indicates that formation of stereotypic exostoses requires a significant, but not complete, loss of Ext expression.

  7. local Ext1 expression and heparan sulfate production are needed to maintain the phenotype and function of joint-forming cells.

  8. Ext1 has a role in regulation of bone morphogenic protein signaling and skeletal defects

  9. inactivation of Ext1 in a small fraction of chondrocytes is sufficient for the development of osteochondromas and other skeletal defects associated with multiple hereditary exostoses

  10. for a model of multiple osteochondromas, we created the chimeric tissue genotype of somatic loss of heterozygosity, by conditionally inactivating Ext1 in chondrocytes

Human Exostosin 1 (EXT1) interaction partners

  1. We found that the prevalence of EXT1 mutations was greater than that of EXT2 mutations in Japanese multiple osteochondromas families.

  2. Ext1 heterozygosity causes a modest effect on postprandial lipid clearance in humans

  3. EXT1 mutation is associated with multiple osteochondromatosis.

  4. Heterozygous loss of function of EXT1 and EXT2 results in a decreased arteriolar endothelial glycocalyx but improved flow mediated vasodilation.

  5. there is a putative genetic connection between TCF7L2 and EXT in the context of Hereditary Multiple Exostoses

  6. loss of function of EXT1 subjects with hereditary multiple exostoses affects pancreatic insulin (show INS Proteins) secretion capacity and development.

  7. Results provide a new frameshift mutation in EXT1, further emphasizing the dysfunction of the EXT gene family as a cause of hereditary multiple exostosis.

  8. exostosin 1 (EXT1), which is involved in biosynthesis of heparan sulfate, plays a role in filovirus entry

  9. EXT1 and EXT2 heterozygous mutations in 18 (54.6 %) and ten (30.3 %) probands respectively, which represents a total of 28 (84.9 %) index cases.

  10. a novel disease-causing EXT1 mutation in a pedigree with Hereditary multiple exostoses

EXT1 Protein Profile

Protein Summary

This gene encodes an endoplasmic reticulum-resident type II transmembrane glycosyltransferase involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type I form of multiple exostoses.

Gene names and symbols associated with Exostosin 1 Proteins (EXT1)

  • exostoses (multiple) 1b (ext1b)
  • exostoses (multiple) 1 (Ext1)
  • exostoses (multiple)-like 1 (EXTL1)
  • exostosin 1 (EXT1)
  • exostosin glycosyltransferase 1 (EXT1)
  • exostosin glycosyltransferase 1 (Ext1)
  • exostosin glycosyltransferase 1 (ext1)
  • exostosin-1-like (LOC100537794)
  • AA409028 protein
  • EXT protein
  • LGCR protein
  • LGS protein
  • TRPS2 protein
  • TTV protein
  • xext1 protein

Protein level used designations for Exostosin 1 Proteins (EXT1)

exostosin-1b , glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase 1b , multiple exostoses protein 1 homolog b , exostosin-1 , glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase , multiple exostoses protein 1 homolog , Heparan sulfate copolymerase , Multiple exostoses protein 1 homolog , exostosin 1 , exostoses-like 1 , Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase , exostoses (multiple) 1 , Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase , Langer-Giedion syndrome chromosome region , N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase , multiple exostoses protein 1 , putative tumor suppressor protein EXT1

GENE ID SPECIES
497280 Danio rerio
14042 Mus musculus
100689334 Cricetulus griseus
100347418 Oryctolagus cuniculus
538602 Bos taurus
2131 Homo sapiens
299907 Rattus norvegicus
399115 Xenopus laevis
100537794 Danio rerio
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