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Exportins, such as XPO6, recruit cargo in the nucleoplasm in the presence of RAN (MIM 601179)-GTP and form ternary export complexes. Additionally we are shipping Exportin 6 Antibodies (8) and Exportin 6 Proteins (3) and many more products for this protein.
Data suggest actin accumulation in senescent cells is due to the failure of RanGTP restoration with ATP deficiency and NTF2 (show NUTF2 ELISA Kits) accumulation, resulting in decreased actin export via Exp6 inactivation.
identify exportin 6 (Exp6) as a novel family member from higher eukaryotes and show that it mediates nuclear export of profilin.actin complexes
Measurements of nuclear export rates and depletion studies clarified that nuclear export of actin is mediated by exportin 6.
The protein encoded by this gene is a member of the importin-beta family. Members of this family are regulated by the GTPase Ran to mediate transport of cargo across the nuclear envelope. This protein has been shown to mediate nuclear export of profilin-actin complexes. A pseudogene of this gene is located on the long arm of chromosome 14. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
, exportin 6
, ran-binding protein 20
, RAN binding protein 20