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Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.. Additionally we are shipping ELFN1 Antibodies (17) and many more products for this protein.
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Damaging missense mutations of ELFN1, that are clustered in the carboxy-terminal region required for mGl (show SST Proteins)uR7 recruitment, are found in patients with epi (show CA1 Proteins)lepsy and attention deficit hyperactivity disorder.
Elfn1 protein increases during postnatal development and localizes to postsynaptic sites of somatostatin (show SST Proteins)-containing interneurons in the hippocampal CA1 (show CA1 Proteins) stratum oriens and dentate gyrus hilus.Elfn1 recruits mGluR7 (show GRM2 Proteins) to synaptic sites.
Mutation of Elfn1 in mice causes seizures and hyperactivity.
postsynaptic expression of Elfn1 in oriens-lacunosum moleculare interneurons regulates presynaptic release probability, which confers target-specific synaptic properties to pyramidal cell axons.
Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.
extracellular leucine-rich repeat and fibronectin type III containing 1
, extracellular leucine-rich repeat and fibronectin type-III domain-containing protein 1
, protein ELFN1
, protein phosphatase 1 regulatory subunit 28
, protein phosphatase 1, regulatory subunit 28