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ECM1 encodes a soluble protein that is involved in endochondral bone formation, angiogenesis, and tumor biology. Additionally we are shipping ECM1 Antibodies (82) and ECM1 Kits (38) and many more products for this protein.
Showing 9 out of 9 products:
Mouse (Murine) ECM1 Protein expressed in Human Cells - ABIN2007680
Smits, Ni, Feng, Wauters, Van Hul, Boutaibi, Dillon, Merregaert: The human extracellular matrix gene 1 (ECM1): genomic structure, cDNA cloning, expression pattern, and chromosomal localization. in Genomics 1998
Show all 5 references for ABIN2007680
ECM1, which displayed a high expression in hepatocellular carcinoma (HCC (show FAM126A Proteins)) specimens, was closely associated with clinicopathologic data and may promote migration and invasion of HCC (show FAM126A Proteins) cells by inducing epithelia-mesenchymal transition.
Cell invasion (matrigel) was reduced only in the Hs578T cells (p < 0.01). Silencing decreased the expression of the prometastatic molecules S100A4 (show S100A4 Proteins) and TGFbetaR2 in both cell lines and CD44 (show CD44 Proteins) in Hs578T cells. We conclude that ECM1 is a key player in the metastatic process and regulates the actin cytoskeletal architecture of aggressive breast cancer cells at least in part via alterations in S100A4 (show S100A4 Proteins) and Rho A (show RHOA Proteins).
Overexpression of miR (show MLXIP Proteins)-486-3p inhibited cell growth and metastasis by targeting ECM1.
For 1q21 loci, we confirmed gene ECM1 as the most plausible gene from this region to be involved in pathogenesis of inflammatory bowel disease
In conclusion, the domain-specific anti-ECM1 MAbs produced in this study should provide a useful tool for investigating ECM1's biological functions, and cellular pathways in which it is involved.
Lipoid proteinosis is a rare autosomal recessive disorder caused by mutations in ECM1, encoding extracellular matrix protein 1, a glycoprotein expressed in many organs and which has important protein-protein interactions in tissue homeostasis
MMP-2 (show MMP2 Proteins) protein and ECM1 gene are useful preoperative markers for defining malignancy in suspicious thyroid nodules
association between beta-catenin (show CTNNB1 Proteins) and the MUC1 (show MUC1 Proteins) cytoplasmic tail was increased by ECM1
Lipoidproteinosis results from a large homozygous deletion of ECM1 gene in a Chinese family.
High extracellular matrix protein-1 expression is associated with the growth, metastasis and angiogenesis of laryngeal carcinoma
HA accumulation primes the vasculature for atherosclerosis by crosslinking and reorganizing the extracellular matrix (ECM (show MMRN1 Proteins)) and by pushing VSMC differentiation towards a less mature phenotype.
Retinoid signaling in the stroma activates expression of Ecm1, which in turn down-regulates Ret (show RET Proteins) expression in the ureteric bud cleft, where bifurcation normally occurs and normal branching progresses.
This gene encodes a soluble protein that is involved in endochondral bone formation, angiogenesis, and tumor biology. It also interacts with a variety of extracellular and structural proteins, contributing to the maintenance of skin integrity and homeostasis. Mutations in this gene are associated with lipoid proteinosis disorder (also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease) that is characterized by generalized thickening of skin, mucosae and certain viscera. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.
extracellular matrix protein 1
, secretory component p85