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Eyes Absent Homolog 4 (Drosophila) Proteins (EYA4)

EYA4 encodes a member of the eyes absent (EYA) family of proteins. Additionally we are shipping EYA4 Antibodies (57) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EYA4 14051  
EYA4 2070 O95677
Rat EYA4 EYA4 292172  
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Top EYA4 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Takifugu rubripes His tag   1 mg Log in to see 56 to 66 Days
$2,234.83
Details

EYA4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Eyes Absent Homolog 4 (Drosophila) (EYA4) Interaction Partners

Mouse (Murine) Eyes Absent Homolog 4 (Drosophila) (EYA4) interaction partners

  1. results implicate Eya4/Six1 (show SIX1 Proteins) regulates normal cardiac function via p27 (show CDKN1B Proteins)/casein kinase-2alpha/histone deacetylase 2 (show HDAC2 Proteins) and indicate that mutations within this transcriptional complex and signaling cascade lead to the development of cardiomyopathy.

  2. constructs of the homologous region ( Eya1HR and Eya4HR) interact with Six1 (show SIX1 Proteins) prey constructs, although no interaction with Dach1 (show DACH1 Proteins) prey was demonstrable

  3. Eya4(-/-) mice developed otitis media with effusion; anatomic studies revealed abnormal middle ear cavity and eustachian tube dysmorphology.

  4. that Eyes absent 4 (EYA4), originally identified as a co-transcription factor, stimulates the expression of IFN-beta (show IFNB1 Proteins) and CXCL10 (show CXCL10 Proteins) in response to the undigested DNA of apoptotic cells

Human Eyes Absent Homolog 4 (Drosophila) (EYA4) interaction partners

  1. results implicate Eya4/Six1 (show SIX1 Proteins) regulates normal cardiac function via p27 (show PAK2 Proteins)/casein kinase-2alpha/histone deacetylase 2 (show HDAC2 Proteins) and indicate that mutations within this transcriptional complex and signaling cascade lead to the development of cardiomyopathy.

  2. In a Dutch family with c.464del EYA4 mutation, hearing impairment begins as a mid-frequency hearing impairment in childhood and develops into a high-frequency, moderate hearing impairment later in life.

  3. Genetic variations in the EYA4, GRHL2 (show GRHL2 Proteins) and DFNA5 (show DFNA5 Proteins) genes and their interactions with occupational noise exposure may play an important role in the incidence of noise-induced hearing loss (NIHL).

  4. analysis of an EYA4 mutation causing hearing loss in a Chinese DFNA family

  5. A novel missense mutation c.1643C>G (p.T548R) in EYA4 may cause autosomal dominant non-syndromic hearing impairment.

  6. EYA4 mutations are associated with autosomal dominant non-syndromic hearing loss.

  7. Exome Sequencing Identifies a Mutation in EYA4 as a Novel Cause of Autosomal Dominant Non-Syndromic Hearing Loss

  8. EYA4 methylation may be identified in stool samples.

  9. Results provide molecular and clinical information in order to gain improved understanding of the pathogenesis of DFNA10 protein EYA4 mutations and the genotypephenotype correlations of DFNA10 hearing loss.

  10. Autosomal dominant hearing impairment due to a novel EYA4 frameshift mutation:a novel heterozygous frame-shift mutation (c.579_580insTACC, p.(Asp194Tyrfs*52)) in EYA4 was identified that truncates the so-called variable region of the protein.

EYA4 Protein Profile

Protein Summary

This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant nonsyndromic sensorineural 10 locus. Defects in this gene are also associated with dilated cardiomyopathy 1J. Three transcript variants encoding distinct isoforms have been identified for this gene.

Gene names and symbols associated with EYA4

  • eyes absent 4 homolog (Drosophila) (Eya4)
  • eyes absent homolog 4 (Drosophila) (EYA4)
  • eyes absent homolog 4 (Drosophila) (Eya4)
  • B130023L16Rik protein
  • CMD1J protein
  • DFNA10 protein

Protein level used designations for EYA4

eyes absent homolog 4 , dJ78N10.1 (eyes absent) , eyes absent 4

GENE ID SPECIES
14051 Mus musculus
2070 Homo sapiens
395716 Gallus gallus
483991 Canis lupus familiaris
100157256 Sus scrofa
538786 Bos taurus
292172 Rattus norvegicus
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