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FBXO21 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. Additionally we are shipping F-Box Protein 21 Antibodies (75) and F-Box Protein 21 Kits (12) and many more products for this protein.
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Ser291-phosphorylated form of the multifunctional protein and stem cell marker, CD44 (show CD44 Proteins), inhibits FBXO21-directed degradation of P-gp (show ABCB4 Proteins).
SCF (show KITLG Proteins)(FBXO21) polyubiquitylates EID1 (show EID1 Proteins) both in vitro and in vivo and is required for the efficient degradation of EID1 (show EID1 Proteins) in both cycling and quiescent cells.
The results suggest that EID1 (show EID1 Proteins) is a bona fide substrate of FBXO21 and that the control of EID1 (show EID1 Proteins) abundance by SCF (show KITLG Proteins)(FBXO)(21) might affect the transcriptional repression activity of EID1 (show EID1 Proteins).
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants.
F-box only protein 21
, F-box protein 21