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FBXO4 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. Additionally we are shipping F-Box Protein 4 Antibodies (82) and F-Box Protein 4 Kits (15) and many more products for this protein.
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results define the impact of alternative splicing on Fbx4 function, and suggest that the attenuated cyclin D1 (show CCND1 Proteins) degradation by these novel Fbx4 isoforms provides a new insight for aberrant cyclin D1 (show CCND1 Proteins) expression in human cancers.
The FBXO4 I377M mutant exhibits impaired cyclin D1 recruitment and ubiquitylation.
14-3-3varepsilon binds to Ser12-phosphorylated Fbx4 to mediate dimerization and function.
Biochemical studies indicate that both the N-terminal domain and a loop connecting the linker and C-terminal domain of Fbx4 are critical for the dimerization and activation of the protein.
results reveal an atypical small GTPase (show RACGAP1 Proteins) domain within Fbx4 as a substrate-binding motif for SCF (show KITLG Proteins)(Fbx4) and uncover a mechanism for selective ubiquitination and degradation of TRF1 (show TERF1 Proteins) in telomere homeostasis control
Fbx4 is a central regulator of Pin2/TRF1 (show TERF1 Proteins) protein abundance and alterations in the stability of Pin2/TRF1 (show TERF1 Proteins) can have a dramatic impact on telomere length
SCF (show KITLG Proteins)(FBX4-alphaB crystallin (show CRYAB Proteins)) is an E3 ubiquitin ligase (show MUL1 Proteins) that promotes ubiquitin-dependent degradation of Thr286-phosphorylated cyclin D1 (show CCND1 Proteins).
Mutations in Fbx4 inhibit dimerization of the SCF (show KITLG Proteins)(Fbx4) ligase and contribute to cyclin D1 (show CCND1 Proteins) overexpression in human cancer.
Collectively, our data support a role for FBXO4 as a suppressor of esophageal tumorigenesis
This study demonstrates that Fbxo4 deficiency induces Braf-driven melanoma and that this phenotype depends on cyclin D1 accumulation in mice, underscoring the importance of this ubiquitin ligase in tumor suppression.
Fbx4 expression is essential for cell homeostasis in somatic cells. Fbx4 ablation predisposes mice to multiple tumor phenotypes, with concomitant cyclin D1 (show CCND1 Proteins) deregulation and nuclear accumulation
Lysine 269 is essential for cyclin D1 (show CCND1 Proteins) ubiquitylation by the SCF (show KITLG Proteins)(Fbx4/alphaB-crystallin (show CRYAB Proteins)) ligase.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants.
F-box protein 4
, F-box only protein 4
, F-box only protein 4-like
, F-box protein Fbx4