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F-Box Protein 4 Proteins (FBXO4)

FBXO4 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. Additionally we are shipping F-Box Protein 4 Antibodies (85) and F-Box Protein 4 Kits (15) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FBXO4 26272 Q9UKT5
FBXO4 106052 Q8CHQ0
Rat FBXO4 FBXO4 310363  
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Top F-Box Protein 4 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,067.17
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

FBXO4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for F-Box Protein 4 (FBXO4) Interaction Partners

Human F-Box Protein 4 (FBXO4) interaction partners

  1. results define the impact of alternative splicing on Fbx4 function, and suggest that the attenuated cyclin D1 (show CCND1 Proteins) degradation by these novel Fbx4 isoforms provides a new insight for aberrant cyclin D1 (show CCND1 Proteins) expression in human cancers.

  2. The FBXO4 I377M mutant exhibits impaired cyclin D1 recruitment and ubiquitylation.

  3. 14-3-3varepsilon binds to Ser12-phosphorylated Fbx4 to mediate dimerization and function.

  4. Biochemical studies indicate that both the N-terminal domain and a loop connecting the linker and C-terminal domain of Fbx4 are critical for the dimerization and activation of the protein.

  5. results reveal an atypical small GTPase (show RACGAP1 Proteins) domain within Fbx4 as a substrate-binding motif for SCF (show KITLG Proteins)(Fbx4) and uncover a mechanism for selective ubiquitination and degradation of TRF1 (show TERF1 Proteins) in telomere homeostasis control

  6. Fbx4 is a central regulator of Pin2/TRF1 (show TERF1 Proteins) protein abundance and alterations in the stability of Pin2/TRF1 (show TERF1 Proteins) can have a dramatic impact on telomere length

  7. SCF (show KITLG Proteins)(FBX4-alphaB crystallin (show CRYAB Proteins)) is an E3 ubiquitin ligase (show MUL1 Proteins) that promotes ubiquitin-dependent degradation of Thr286-phosphorylated cyclin D1 (show CCND1 Proteins).

  8. Mutations in Fbx4 inhibit dimerization of the SCF (show KITLG Proteins)(Fbx4) ligase and contribute to cyclin D1 (show CCND1 Proteins) overexpression in human cancer.

Mouse (Murine) F-Box Protein 4 (FBXO4) interaction partners

  1. Collectively, our data support a role for FBXO4 as a suppressor of esophageal tumorigenesis

  2. This study demonstrates that Fbxo4 deficiency induces Braf-driven melanoma and that this phenotype depends on cyclin D1 accumulation in mice, underscoring the importance of this ubiquitin ligase in tumor suppression.

  3. Fbx4 expression is essential for cell homeostasis in somatic cells. Fbx4 ablation predisposes mice to multiple tumor phenotypes, with concomitant cyclin D1 (show CCND1 Proteins) deregulation and nuclear accumulation

  4. SCF (show KITLG Proteins)(FBX4-alphaB crystallin (show CRYAB Proteins)) is an E3 ubiquitin ligase (show MUL1 Proteins) that promotes ubiquitin-dependent degradation of Thr286-phosphorylated cyclin D1 (show CCND1 Proteins).

  5. Lysine 269 is essential for cyclin D1 (show CCND1 Proteins) ubiquitylation by the SCF (show KITLG Proteins)(Fbx4/alphaB-crystallin (show CRYAB Proteins)) ligase.

F-Box Protein 4 (FBXO4) Protein Profile

Protein Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants.

Gene names and symbols associated with F-Box Protein 4 Proteins (FBXO4)

  • F-box protein 4 (FBXO4)
  • F-box protein 4 (fbxo4)
  • F-box only protein 4 (fbx4)
  • F-box protein 4 (Fbxo4)
  • 1700096C12Rik protein
  • AI851261 protein
  • AW494535 protein
  • Fbx4 protein
  • FBXO4 protein

Protein level used designations for F-Box Protein 4 Proteins (FBXO4)

F-box protein 4 , F-box only protein 4 , F-box only protein 4-like , F-box protein Fbx4

GENE ID SPECIES
431586 Gallus gallus
548694 Xenopus (Silurana) tropicalis
697007 Macaca mulatta
737372 Pan troglodytes
783766 Bos taurus
100158284 Xenopus laevis
100406305 Callithrix jacchus
100600195 Nomascus leucogenys
100194812 Salmo salar
26272 Homo sapiens
106052 Mus musculus
489220 Canis lupus familiaris
534852 Bos taurus
310363 Rattus norvegicus
101116349 Ovis aries
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