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FBXO7 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. Additionally we are shipping F-Box Protein 7 Kits (15) and F-Box Protein 7 Proteins (4) and many more products for this protein.
Showing 10 out of 22 products:
Human Polyclonal FBXO7 Primary Antibody for IF, IHC (p) - ABIN525424
Chen, Chen, Huang, Juan, Chen, Chen, Lin, Lee, Lee, Lee-Chen, Lai, Wu: FBXO7 Y52C polymorphism as a potential protective factor in Parkinson's disease. in PLoS ONE 2014
Cow (Bovine) Polyclonal FBXO7 Primary Antibody for IP, WB - ABIN2774701
Chang, Cheng, Chang, Jong, Yuo: The F-box protein Fbxo7 interacts with human inhibitor of apoptosis protein cIAP1 and promotes cIAP1 ubiquitination. in Biochemical and biophysical research communications 2006
analysis of the zebrafish model of Fbxo7 mutations with a role in levodopa-responsive parkinsonism with severe loss of nigrostriatal dopaminergic neurons
The mutations of F-box protein 7 (FBXO7) gene (T22M, R378G and R498X) are associated with autosomal recessive juvenile-onset Parkinson's disease We demonstrated wild-type FBXO7 is a stress response protein with both cytoprotective and neurotoxic roles
This is first time a FBXO7 mutation has been identified that causes phenotype compatible with typical idiopathic Parkinson's disease and presents with some of its common nonmotor features
High expression of PARK15 might lead to the occurrence of non-small-cell lung cancer.
genetic analysis of this Turkish family and the Italian PARK15 family reported previously revealed that the c.1492C > T mutation is present on two different haplotypes in the Italian family
in addition to the parkinsonian-pyramidal phenotype, in connection with FBXO7 mutations and points to an intrafamilial phenotypic variation
Cys52 variant of FBXO7 may contribute to reduced Parkinson's disease susceptibility in Chinese
The involvement of the FBXO7 gene in PD is very rare, at least in this population from southern Spain.
The crystal structure of the Fbxo7 FP domain is reported at 2.0 A resolution. The Fbxo7 FP domain adopts an alpha/beta-fold similar to that of the PI31 (show PSMF1 Antibodies) FP domain.
A mutational analysis of the FBXO7 gene in Taiwanese patients with Parkinson's disease (PD) does not show a potential pathophysiological role in PD.
This study showed that Fbxo7 participates in mitochondrial maintenance through direct interaction with PINK1 (show PINK1 Antibodies) and Parkin (show PARK2 Antibodies) and acts in Parkin (show PARK2 Antibodies)-mediated mitophagy.
Report defective erythropoiesis in transgenic mouse with reduced Fbxo7 expression due to decreased erythrocyte p27 (show CDKN1B Antibodies) expression.
2 PDX models showed gained mutations such as PIK3CA (show PIK3CA Antibodies) or FBWX7 mutation. Ten patient-derived advanced colon cancer xenograft models were established.
The physiological effect of reduced levels of Fbxo7 in mice showed significantly increased pro-B cell and pro-erythroblast populations, consistent with Fbxo7 having an anti-proliferative function and/or a role in promoting maturation of precursor cells.
Fbxo7 specifically regulated D cyclin (show PCNA Antibodies)/cdk6 (show CDK6 Antibodies) complexes; it was highly expressed in epithelial tumors, but not in normal tissues, suggesting that it may have a proto-oncogenic role in human cancers.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined.
F-box only protein 7
, F-box protein 7
, F-box only protein 7-like