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F-Box and Leucine-Rich Repeat Protein 3 Proteins (FBXL3)

FBXL3 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. Additionally we are shipping F-Box and Leucine-Rich Repeat Protein 3 Antibodies (58) and F-Box and Leucine-Rich Repeat Protein 3 Kits (24) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FBXL3 26224 Q9UKT7
FBXL3 50789 Q8C4V4
Rat FBXL3 FBXL3 306129  
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Top F-Box and Leucine-Rich Repeat Protein 3 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

FBXL3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for F-Box and Leucine-Rich Repeat Protein 3 (FBXL3) Interaction Partners

Human F-Box and Leucine-Rich Repeat Protein 3 (FBXL3) interaction partners

  1. Data show that CRISPR/Cas9 genome editing generated F-box and leucine-rich repeat protein 3 (Fbxl3) knockout in circadian clock model U2OS cells.

  2. Substrate binding promotes formation of the Skp1 (show SKP1 Proteins)-Cul1 (show CUL1 Proteins)-Fbxl3 (SCF (show KITLG Proteins)(Fbxl3)) protein complex.

  3. Mutation in the Fbxl3 protein reveals distinct roles for CRY1 (show CRY1 Proteins) and CRY2 (show CRY2 Proteins) in the circadian molecular clockwork.

  4. crystal structures of mammalian CRY2 (show CRY2 Proteins) in its apo (show C9orf3 Proteins), FAD (show BRCA2 Proteins)-bound and FBXL3-SKP1 (show SKP1 Proteins)-complexed forms

  5. study demonstrates that the SCF (show KITLG Proteins)(Fbxl3)ubiquitin ligase controls the oscillations of the circadian clock by mediating the degradation of Cry1 (show CRY1 Proteins) and Cry2 (show CRY2 Proteins) proteins

Mouse (Murine) F-Box and Leucine-Rich Repeat Protein 3 (FBXL3) interaction partners

  1. Substrate binding promotes formation of the Skp1 (show SKP1 Proteins)-Cul1 (show CUL1 Proteins)-Fbxl3 (SCF (show KITLG Proteins)(Fbxl3)) protein complex.

  2. By analyzing the Fbxl3 and Cryptochrome 1 (show CRY1 Proteins) double-mutant mice, we found that FBXL3 also regulates the amplitudes of E-box-driven gene expression.

  3. crystal structures of mammalian CRY2 (show CRY2 Proteins) in its apo (show C9orf3 Proteins), FAD-bound and FBXL3-SKP1 (show SKP1 Proteins)-complexed forms

  4. FBXL21 (show FBXL21 Proteins) plays a dual role: protecting CRY 1 (show CRY1 Proteins)/2 proteins (CRY (show CRY2 Proteins)) from FBXL3 degradation in the nucleus and promoting CRY (show CRY2 Proteins) degradation within the cytoplasm.

  5. results are consistent with previous studies of mutants with extended circadian periods and suggest that disruption of FBXL3 is associated with mania-like behaviours in both mice and humans

  6. In Ovtm mice, expression of the PERIOD proteins is reduced; however, the CRY (show CRY2 Proteins) proteins are unchanged; the loss of FBXL3 function leads to a stabilization of the CRY (show CRY2 Proteins) proteins, which leads to a global transcriptional repression of the Per and Cry (show CRY2 Proteins) genes.

  7. study demonstrates that the SCF (show KITLG Proteins)(Fbxl3)ubiquitin ligase (show RNF123 Proteins) controls the oscillations of the circadian clock by mediating the degradation of Cry1 (show CRY1 Proteins) and Cry2 (show CRY2 Proteins) proteins

  8. studies reveal a central role for Fbxl3 in mammalian circadian timekeeping

F-Box and Leucine-Rich Repeat Protein 3 (FBXL3) Protein Profile

Protein Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus.

Gene names and symbols associated with FBXL3

  • F-box and leucine-rich repeat protein 3 (fbxl3)
  • F-box and leucine-rich repeat protein 3 (FBXL3)
  • similar to F-box and leucine-rich repeat protein 8 (FBXL3)
  • F-box and leucine-rich repeat protein 3 (Fbxl3)
  • F-box/LRR-repeat protein 3 (AT5G01720)
  • AU041772 protein
  • AW212966 protein
  • F7A7.240 protein
  • F7A7_240 protein
  • FBK protein
  • FBL3 protein
  • Fbl3a protein
  • FBXL3 protein
  • Fbxl3a protein
  • Ovtm protein
  • Play68 protein

Protein level used designations for FBXL3

F-box and leucine-rich repeat protein 3 , F-box/LRR-repeat protein 3 , F-box/LRR-repeat protein 3-like , f-box/LRR-repeat protein 3-like , similar to F-box and leucine-rich repeat protein 8 , F-box and leucine-rich repeat protein 3A , F-box protein Fbl3a , F-box/LRR-repeat protein 3A , F-box and leucine-rich repeat protein 3a , protein after-hours , protein overtime

GENE ID SPECIES
548882 Xenopus (Silurana) tropicalis
699028 Macaca mulatta
100010986 Monodelphis domestica
100052811 Equus caballus
100169937 Ovis aries
100413726 Callithrix jacchus
100450887 Pongo abelii
100556180 Anolis carolinensis
698286 Macaca mulatta
100081796 Ornithorhynchus anatinus
100469040 Ailuropoda melanoleuca
100580993 Nomascus leucogenys
26224 Homo sapiens
485499 Canis lupus familiaris
100152980 Sus scrofa
50789 Mus musculus
306129 Rattus norvegicus
564855 Danio rerio
446817 Xenopus laevis
428048 Gallus gallus
540712 Bos taurus
831688 Arabidopsis thaliana
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