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F-Box and Leucine-Rich Repeat Protein 5 Proteins (FBXL5)

FBXL5 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. Additionally we are shipping FBXL5 Antibodies (59) and FBXL5 Kits (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FBXL5 26234 Q9UKA1
FBXL5 242960 Q8C2S5
Rat FBXL5 FBXL5 305424  
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Top FBXL5 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

FBXL5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for F-Box and Leucine-Rich Repeat Protein 5 (FBXL5) Interaction Partners

Human F-Box and Leucine-Rich Repeat Protein 5 (FBXL5) interaction partners

  1. FBXL5 regulates cortactin (show CTTN Proteins) through induction of its ubiquitylation, and FBXL5 similarly regulates Snail1 (show SNAI1 Proteins).

  2. FBXL5-mediated degradation of CITED2 (show CITED2 Proteins) leads to the activation of HIF-1alpha (show HIF1A Proteins).

  3. Data suggest a mechanism for the negative regulation of cortactin (show CTTN Proteins) by FBXL5 protein in gastric cancer cells migration.

  4. results thus suggest that HERC2 regulates the basal turnover of FBXL5, and that this ubiquitin-dependent degradation pathway contributes to the control of mammalian iron metabolism

  5. F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis

  6. Data indicate that F-box and leucine-rich repeat protein 5 (FBXL5)-Hr (hemerythrin-like domain) undergoes substantive structural changes when iron becomes limiting, accounting for its switch-like behavior.

  7. Detailed molecular and structural characterization of the ligand-responsive hemerythrin domain provides insights into the mechanisms by which FBXL5 serves as a unique mammalian metabolic sensor.

  8. iron homeostasis is regulated by a proteolytic pathway that couples IRP2 (show IREB2 Proteins) degradation to intracellular iron levels through the stability and activity of FBXL5

  9. observations suggest a mechanistic link between iron sensing via the FBXL5 hemerythrin domain, IRP2 (show IREB2 Proteins) regulation, and cellular responses to maintain mammalian iron homeostasis

  10. Our findings provide a potential mechanism by which p150(Glued (show DCTN1 Proteins)) protein function is regulated by SCFs.

Mouse (Murine) F-Box and Leucine-Rich Repeat Protein 5 (FBXL5) interaction partners

  1. we describe the iron and oxygen sensing mechanisms of the FBXL5 Hr-like domain and its role in mediating ROS (show ROS1 Proteins) biology.

  2. F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis

  3. The FBXL5-IRP2 (show IREB2 Proteins) axis is integral to control of iron metabolism in vivo.

FBXL5 Protein Profile

Protein Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus.

Gene names and symbols associated with FBXL5

  • F-box and leucine-rich repeat protein 5 (FBXL5)
  • F-box and leucine-rich repeat protein 5 (fbxl5)
  • F-box and leucine-rich repeat protein 5 (LOC100351566)
  • F-box and leucine-rich repeat protein 5 (Fbxl5)
  • Fbl4 protein
  • FBL5 protein
  • FBXL5 protein
  • Fir4 protein
  • FLR1 protein
  • MGC53238 protein
  • wu:fb52d06 protein

Protein level used designations for FBXL5

F-box and leucine-rich repeat protein 5 , F-box/LRR-repeat protein 5 , F-box/LRR-repeat protein 5-like , F-box protein FBL4/FBL5 , F-box protein FBL5 , p45SKP2-like protein

GENE ID SPECIES
479085 Canis lupus familiaris
100511143 Sus scrofa
422829 Gallus gallus
380440 Xenopus laevis
432131 Xenopus laevis
461125 Pan troglodytes
496483 Xenopus (Silurana) tropicalis
100012405 Monodelphis domestica
100074228 Ornithorhynchus anatinus
100173556 Pongo abelii
100351566 Oryctolagus cuniculus
100388303 Callithrix jacchus
100605502 Nomascus leucogenys
26234 Homo sapiens
519695 Bos taurus
242960 Mus musculus
305424 Rattus norvegicus
322181 Danio rerio
101106171 Ovis aries
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