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F-Box and WD Repeat Domain Containing 5 Proteins (FBXW5)

FBXW5 encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. Additionally we are shipping FBXW5 Antibodies (39) and FBXW5 Kits (15) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FBXW5 54461 Q969U6
Rat FBXW5 FBXW5 362081 Q4KLI9
FBXW5 30839 Q9QXW2
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Top FBXW5 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

FBXW5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for F-Box and WD Repeat Domain Containing 5 (FBXW5) Interaction Partners

Human F-Box and WD Repeat Domain Containing 5 (FBXW5) interaction partners

  1. oxidative stress induces Tnfaip8 l1/Oxi-beta, which results in increased autophagy by its exclusive binding with FBXW5 to stabilize TSC2

  2. DLC1 (show DYNLL1 Proteins) was ubiquitinated and degraded by cullin 4A (show CUL4A Proteins)-RING ubiquitin ligase (CRL4A) complex interaction with DDB1 (show DDB1 Proteins) and the FBXW5 substrate receptor.

  3. Identify Fbxw5-driven fluctuation of Eps8 (show EPS8 Proteins) levels as an important mechanism that contributes to cell-shape changes during entry into-and exit from-mitosis.

  4. Fbxw5 enhances sumoylation of nuclear c-Myb (show MYB Proteins)

  5. FBXW5 levels are controlled by the anaphase-promoting (APC (show APC Proteins)/C) complex, which targets FBXW5 for degradation during mitosis and G1, thereby helping to reset the centrosome duplication machinery.

  6. Results indicate that FBW5-DDB1 (show DDB1 Proteins)-CUL4-ROC1 (show RIT1 Proteins) is an E3 ubiquitin ligase (show MUL1 Proteins) regulating TSC2 protein stability and TSC (show SLC12A3 Proteins) complex turnover.

  7. These results suggest that FBXW5 negatively regulates TAK1 (show MAP3K7 Proteins) in the IL-1beta (show IL1B Proteins) signaling pathway.

FBXW5 Protein Profile

Protein Summary

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented.

Gene names and symbols associated with FBXW5

  • F-box and WD repeat domain containing 5 (FBXW5)
  • F-box and WD repeat domain containing 5 (Fbxw5)
  • F-box and WD-40 domain protein 5 (Fbxw5)
  • AI159739 protein
  • Fbw5 protein

Protein level used designations for FBXW5

F-box and WD-40 domain protein 5 , F-box/WD repeat-containing protein 5 , F-box and WD-40 domain-containing protein 5 , WD repeat-containing F-box protein FBW5 , F-box protein Fbw5

GENE ID SPECIES
417289 Gallus gallus
100514029 Sus scrofa
517357 Bos taurus
54461 Homo sapiens
362081 Rattus norvegicus
100732858 Cavia porcellus
30839 Mus musculus
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