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anti-F-Box and WD Repeat Domain Containing 8 (FBXW8) Antibodies

FBXW8 encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. Additionally we are shipping FBXW8 Kits (15) and FBXW8 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FBXW8 26259 Q8N3Y1
FBXW8 304522  
FBXW8 231672 Q8BIA4
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Top anti-FBXW8 Antibodies at antibodies-online.com

Showing 10 out of 47 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-FBXW8 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB FBXW8 Antibody (Center) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. FBXW8 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the FBXW8 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB FBXW8 Antibody (Center) (ABIN654676) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-FBXW8 Antibody Titration: 0.2-1 ug/mlPositive Control: ACHN cell lysate WB Suggested Anti-FBXW8  Antibody Titration: 0.2-1 µg/mL  Positive Control: ACHN cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Mouse Un-conjugated ELISA, WB FBXW8 polyclonal antibody (A01), Lot # UMI10060110QCS1 Western Blot analysis of FBXW8 expression in Hela NE Western Blot detection against Immunogen (37.11 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit APC FACS, IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated WB FBXW8 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details

FBXW8 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-FBXW8 Antibodies

  1. Human Polyclonal FBXW8 Primary Antibody for EIA, IHC (p) - ABIN952296 : Tsutsumi, Kuwabara, Arai, Xiao, Decaprio: Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice. in Molecular and cellular biology 2008 (PubMed)
    Show all 3 references for ABIN952296

  2. Human Polyclonal FBXW8 Primary Antibody for ELISA, WB - ABIN565252 : Wei, Yang, Chuang, Yang, Kulp, Lu, Lai, Chen: A novel mechanism by which thiazolidinediones facilitate the proteasomal degradation of cyclin D1 in cancer cells. in The Journal of biological chemistry 2008 (PubMed)
    Show all 2 references for ABIN565252

  3. Cow (Bovine) Polyclonal FBXW8 Primary Antibody for WB - ABIN2786275 : Lin, Fu, Zhao, Lin, Zou, Liu, Zhu, Wang, Yu: Fbxw8 is involved in the proliferation of human choriocarcinoma JEG-3 cells. in Molecular biology reports 2011 (PubMed)
    Show all 2 references for ABIN2786275

  4. Human Polyclonal FBXW8 Primary Antibody for FACS, IHC (p) - ABIN654676 : Wang, Chen, Lin, Li, Zhou, Liu, Logsdon, Jin, Abbruzzese, Tan, Wang: The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1. in The Journal of biological chemistry 2014 (PubMed)

More Antibodies against FBXW8 Interaction Partners

Human F-Box and WD Repeat Domain Containing 8 (FBXW8) interaction partners

  1. FBXW8 and PARK2 (show PARK2 Antibodies) are sequestrated into insolubility by ATXN2 (show ATXN2 Antibodies) PolyQ expansions, but only FBXW8 expression is dysregulated

  2. findings will shed light the role to mechanism of miR (show MLXIP Antibodies)-218 in regulating JEG-3 cells proliferation via miR (show MLXIP Antibodies)-218/Fbxw8 axis, and miR (show MLXIP Antibodies)-218 may serve as a novel potential therapeutic target in human choriocarcinoma in the future

  3. CUL7 (show CUL7 Antibodies)/Fbxw8 ubiquitin ligase-mediated HPK1 (show MAP4K1 Antibodies) degradation revealed a direct link and novel role of CUL7 (show CUL7 Antibodies)/Fbxw8 ubiquitin ligase in the MAPK (show MAPK1 Antibodies) pathway, which plays a critical role in cell proliferation and differentiation.

  4. Dysregulation of Cul7 (show CUL7 Antibodies) and Fbxw8 expression might affect trophoblast turnover in intrauterine growth restriction.

  5. Growth factor-stimulated TBC1D3 (show TBC1D3 Antibodies) ubiquitination and degradation are regulated by its interaction with CUL7 (show CUL7 Antibodies)-Fbw8.

  6. Fbxw8 plays an essential role in the proliferation of human trophoblast cells, especially JEG-3 cells.

  7. FBXW8 plays an essential role in cancer cell proliferation throug (show CCND1 Antibodies)h proteolysis of cyclin D1. It may (show CDK1 Antibodies) present new opportunities to develop therapies targeting destruction of cyclin D1 or its regulator E3 ligase selectively.

  8. FBXW8-CUL7 (show CUL7 Antibodies) complex plays a significant role in growth control

Mouse (Murine) F-Box and WD Repeat Domain Containing 8 (FBXW8) interaction partners

  1. FBXW8 and PARK2 (show PARK2 Antibodies) are sequestrated into insolubility by ATXN2 (show ATXN2 Antibodies) PolyQ expansions, but only FBXW8 expression is dysregulated

  2. mTORC2 (show CRTC2 Antibodies) negatively feeds back to IRS-1 (show IRS1 Antibodies) via control of Fbw8 stability and localization.

  3. our data support the concept that expanded ATXN2 (show ATXN2 Antibodies) undergoes progressive insolubility and affects PABPC1 (show PABPC1 Antibodies) by a toxic gain-of-function mechanism with tissue-specific effects, which may be partially alleviated by the induction of FBXW8.

  4. Depletion of FBXW8 caused a significant accumulation of cyclin D1 (show CCND1 Antibodies), as well as sequestration of CDK1 (show CDK1 Antibodies) in the cytoplasm. This resulted in a severe reduction of cell proliferation.

  5. Cul7 (show CUL7 Antibodies) forms a heterodimeric complex with Cul1 (show CUL1 Antibodies) in a manner dependent on Fbxw8.

  6. FBXW8-CUL7 (show CUL7 Antibodies) complex plays a significant role in growth control

FBXW8 Antigen Profile

Protein Summary

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

Gene names and symbols associated with FBXW8

  • F-box and WD repeat domain containing 8 (FBXW8) antibody
  • F-box and WD repeat domain containing 8 (Fbxw8) antibody
  • F-box and WD-40 domain protein 8 (Fbxw8) antibody
  • 4930438M06Rik antibody
  • FBW6 antibody
  • FBW8 antibody
  • Fbx29 antibody
  • FBXO29 antibody
  • FBXW6 antibody

Protein level used designations for FBXW8

F-box and WD-40 domain protein 8 , F-box and WD-40 domain-containing protein 8 , F-box only protein 29 , F-box/WD repeat-containing protein 8 , F-box protein FBX29

GENE ID SPECIES
486288 Canis lupus familiaris
26259 Homo sapiens
787118 Bos taurus
304522 Rattus norvegicus
100728842 Cavia porcellus
101108081 Ovis aries
231672 Mus musculus
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