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anti-FANCD2/FANCI-Associated Nuclease 1 (FAN1) Antibodies

FAN1 encodes a member of the myotubularin-related class 1 cysteine-based protein tyrosine phosphatases. Additionally we are shipping FAN1 Kits (2) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FAN1 22909 Q9Y2M0
FAN1 330554 Q69ZT1
FAN1 309256  
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Top anti-FAN1 Antibodies at antibodies-online.com

Showing 10 out of 28 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated IF, WB Western Blot analysis of KIAA1018 expression in transfected 293T cell line by KIAA1018 MaxPab polyclonal antibody.Lane 1: KIAA1018 transfected lysate(58.63 KDa).Lane 2: Non-transfected lysate. KIAA1018 MaxPab polyclonal antibody. Western Blot analysis of KIAA1018 expression in human spleen. 50 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Alkaline Phosphatase (AP) FACS, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Alexa Fluor 594 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 647 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Biotin IHC (p), WB   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit FITC IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

FAN1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-FAN1 Antibodies

  1. Human Polyclonal FAN1 Primary Antibody for IF, WB - ABIN524848 : Sareen, Chaudhury, Adams, Sobeck: Fanconi anemia proteins FANCD2 and FANCI exhibit different DNA damage responses during S-phase. in Nucleic acids research 2012 (PubMed)

More Antibodies against FAN1 Interaction Partners

Human FANCD2/FANCI-Associated Nuclease 1 (FAN1) interaction partners

  1. FAN1 efficiently promoted DNA incision at the proper site of RPA-coated 5'-flapped DNA. Therefore, FAN1 possesses the ability to promote the ICL repair of 5'-flapped DNA covered by RPA.

  2. EXO1 (show EXO1 Antibodies) and FEN1 (show FEN1 Antibodies) cleaved the substrate at the boundary between the single-stranded 5' flap (show ALOX5AP Antibodies) and the duplex, whereas FAN1 (show FSCN1 Antibodies) incised it three to four nucleotides in the double-stranded region.

  3. Detected FAN1 (show FSCN1 Antibodies) mutations in approximately 3% of families who met the Amsterdam criteria for hereditary colorectal cancer and had mismatch repair-proficient cancers with no previously associated mutations.

  4. The crystal structures of human FAN1 (show FSCN1 Antibodies) in complex with a 5' flap (show ALOX5AP Antibodies) DNA substrate show that two FAN1 (show FSCN1 Antibodies) molecules form a head-to-tail dimer to locate the lesion, orient the DNA, and unwind a 5' flap (show ALOX5AP Antibodies) for subsequent incision.

  5. In this work, FAN1 (show FSCN1 Antibodies)-DNA crystal structures and biochemical data reveal that human FAN1 (show FSCN1 Antibodies) cleaves DNA successively at every third nucleotide

  6. Results show that FAN1 (show FSCN1 Antibodies) utilizes its nuclease (show DCLRE1C Antibodies) activity-in cooperation with the BLM-FANCD2 (show FANCD2 Antibodies) complex-to promote replication fork restart and simultaneous suppression of new origin firing.

  7. FAN1 (show FSCN1 Antibodies) encodes a DNA repair enzyme (show LIG4 Antibodies), thus implicating abnormalities in DNA repair in the susceptibility to schizophrenia or autism

  8. FAN1 (show FSCN1 Antibodies) might be a new mitotic substrate of APC (show APC Antibodies)/CCdh1 that plays a key role during mitotic exit.

  9. By exome sequencing, we identified mutations in FAN1 (show FSCN1 Antibodies) as a cause of karyomegalic interstitial nephritis, a disorder that serves as a model for renal fibrosis.

  10. Our results suggest that FAN1 (show FSCN1 Antibodies) has a minor role in interstrand crosslink repair compared with true Fanconi anemia (show PALB2 Antibodies) genes and exclude FAN1 (show FSCN1 Antibodies) as a novel FA gene.

Mouse (Murine) FANCD2/FANCI-Associated Nuclease 1 (FAN1) interaction partners

  1. Fan1 nuclease activity promotes ICL repair in a manner that controls ploidy

  2. ubiquitin-binding zinc finger (UBZ) domain of FAN1, which is needed for interaction with FANCD2, is not required for the initial rapid recruitment of FAN1 to ICLs or for its role in DNA ICL resistance.

  3. Fan1 recruitment enables processing of stalled forks that is essential for genome stability and health.

FAN1 Antigen Profile

Protein Summary

This gene encodes a member of the myotubularin-related class 1 cysteine-based protein tyrosine phosphatases. The encoded protein may be catalytically inactive. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with FAN1

  • FANCD2/FANCI-associated nuclease 1 (FAN1) antibody
  • FANCD2/FANCI-associated nuclease 1 (Fan1) antibody
  • FANCD2/FANCI-associated nuclease 1 (fan1) antibody
  • 6030441H18Rik antibody
  • fi39f01 antibody
  • KIAA1018 antibody
  • KMIN antibody
  • mtmr15 antibody
  • RGD1566323 antibody
  • si:ch211-163b1.2 antibody
  • si:ch211-201b11.2 antibody
  • wu:fd06a07 antibody
  • wu:fi39f01 antibody

Protein level used designations for FAN1

coiled-coil domain-containing protein MTMR15 , fanconi anemia associated nuclease 1 , fanconi-associated nuclease 1 , myotubularin-related protein 15 , myotubularin related protein 15 , Fanconi-associated nuclease 1

GENE ID SPECIES
22909 Homo sapiens
330554 Mus musculus
565458 Danio rerio
100481860 Ailuropoda melanoleuca
415383 Gallus gallus
479017 Canis lupus familiaris
100154519 Sus scrofa
508171 Bos taurus
309256 Rattus norvegicus
Selected quality suppliers for anti-FAN1 (FAN1) Antibodies
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