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Required for eye and embryo development, and plays a role in compound eye assembly and oogenesis respectively.
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Faf inhibits the IMD (show ADM2 Antibodies) pathway by modulating the state of Imd (show ADM2 Antibodies) ubiquitination and/or stability.
Fat facets deubiquitylation of Medea/Smad4 modulates interpretation of a Dpp morphogen gradient
By deubiquitinating Lqf, which enhances the efficiency of Delta internalization, Faf stimulates Delta signaling
Required for eye and embryo development, and plays a role in compound eye assembly and oogenesis respectively. In the larval eye disks, cells outside the assembling facets require this protein for short-range cell interactions that prevent the mystery cells from becoming photoreceptors. It is also required for nuclear migration and cellularization in early embryogenesis and could play a role in pole cell determination, development or function.
, Fat facets