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FAT1 is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. Additionally we are shipping and and many more products for this protein.
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Human Polyclonal FAT1 Primary Antibody for IHC, IHC (p) - ABIN4310665
Morris, Kaufman, Gong, Ramaswami, Walsh, Turcan, Eng, Kannan, Zou, Peng, Banuchi, Paty, Zeng, Vakiani, Solit, Singh, Ganly, Liau, Cloughesy, Mischel, Mellinghoff, Chan: Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation. in Nature genetics 2013
Show all 6 references for ABIN4310665
Low FAT1 expression was associated with poor prognosis in children with medulloblastoma. Furthermore, FAT1 may act on Wnt (show WNT2 Antibodies) signaling pathway to exert its antitumor effect
Recessive mutations in FAT1 cause a distinct renal disease entity in four families with a combination of steroid-resistance nephrotic syndrome, tubular ectasia, haematuria and facultative neurological involvement.
that loss of FAT1 and beta-catenin (show CTNNB1 Antibodies) are associated with breast cancer progression, aggressive behavior, and poor prognosis
FAT1 protein acts upstream of Hippo signalling through TAZ (show TAZ Antibodies) protein to regulate neuronal differentiation.
Fat1 is released from pancreatic cancer cells in its soluble form by ADAM10 (show ADAM10 Antibodies) mediated ectodomain shedding
our data suggest that defective FAT1 is associated with an FSHD-like phenotype.
FAT1 is expressed at lower levels in muscles that are affected at early stages of facioscapulohumeral muscular dystrophy progression.
Analysis revealed an aberrant expression of FAT1 predominantly in mature BCP (show OPN1SW Antibodies)-ALL and thymic T-ALL and a high rate of FAT1 mutations.
FJX1 (show FJX1 Antibodies) does not influence the levels of FAT1 ectodomain phosphorylation.
FAT1 expression in HCC (show FAM126A Antibodies) is regulated via promotor methylation.
studies suggest that Fat1 controls mitochondrial activity to restrain cell growth during the reparative, proliferative state induced by vascular injury. Given recent reports linking Fat1 to cancer, abnormal kidney and muscle development, and neuropsychiatric disease, this Fat1 function may have importance in other settings of altered cell growth and metabolism
Fat1 deletion in podocytes induces abnormal glomerular filtration barrier development leading to podocyte foot process effacement. Fat1 knockdown in renal tubular cells reduces migration, decreases active RAC1/CDC42 (show CDC42 Antibodies) and induces defects in lumen formation.
Fat1 interacts with Fat4 (show FAT4 Antibodies) to regulate neural tube closure, neural progenitor proliferation and apical constriction during mouse brain development.
Fat-1 expression suppresses CD4 (show CD4 Antibodies)+ T-cell activation and differentiation in spleen, and reduces inflammatory cytokines and eotaxin (show CCL11 Antibodies) in bronchoalveolar lavage and lung tissues of mice.
Endogenous synthesis of n-3 PUFA in the fat-1 mouse attains similar kidney n-3 PUFA composition and eicosanoid levels as compared to fish oil feeding.
FAT1 suppression in activated hepatic stellate cells caused a downregulation of NFkappaB activity
Data find that Fat1 and Fat4 (show FAT4 Antibodies) cooperate during mouse development to control renal tubular elongation, cochlear extension, cranial neural tube formation and patterning of outer hair cells in the cochlea.
results confirm a necessary role for FAT1 in the modified adhesion junctions of the renal glomerular epithelial cell and reveal hitherto unsuspected roles for FAT1 in CNS development
Fat1 regulates actin cytoskeletal organization at cell peripheries, thereby modulating cell contacts and polarity.
data are compatible with conservation and sub-functionalization of dachsous 1 (show DCHS1 Antibodies), Fj, and Fat signaling in higher vertebrates.
these data provide new insights into the mechanisms of the association between FAT1 and porcine cumulus cell apoptosis.
This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and\\/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and\\/or alternative promoter usage exist, but they have not been fully described.
FAT tumor suppressor 1
, FAT tumor suppressor homolog 1
, cadherin ME5
, cadherin family member 7
, cadherin-related family member 8
, cadherin-related tumor suppressor homolog
, protein fat homolog
, protocadherin Fat 1
, fat 1 cadherin
, FAT tumor suppressor homolog 1 (Drosophila)
, protocadherin Fat 1-like