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FAT2 is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development.
DeltaNp63alpha (TP63) is co-expressed with FAT2 and Slug in patient tumors and the elevated expression of DeltaNp63alpha, FAT2 and Slug correlated with poor patient outcome.
Human Fat2 is localized at immature adherens junctions in epidermal keratinocytes.
This gene is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has two epidermal growth factor (EGF)-like repeats and one laminin G domain. This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development.
FAT tumor suppressor homolog 2
, cadherin family member 8
, cadherin-related family member 9
, multiple EGF-like domains protein 1
, multiple epidermal growth factor-like domains 1
, multiple epidermal growth factor-like domains protein 1
, protocadherin FAT2
, protocadherin Fat 2