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FBXO25 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. Additionally we are shipping F-Box Protein 25 Antibodies (38) and F-Box Protein 25 Kits (12) and many more products for this protein.
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A sudy of FBXO25 gene expression patterns.
High FBXO25 expression is associated with non-small-cell lung cancer.
FBXO25 functions as a haploinsufficient tumor suppressor in mantle cell lymphoma.
FBXO25 mediates ELK-1 (show ELK1 Proteins) degradation through the ubiquitin proteasome system and thereby plays a role in regulating the activation of ELK-1 (show ELK1 Proteins) pathway in response to mitogens
Altogether, Fbxo25 acts as an ubiquitin E3 ligase to target cardiac transcription factors including Nkx2-5 (show NKX2-5 Proteins), Isl1 (show ISL1 Proteins), and Hand1 (show HAND1 Proteins), indicating that cardiac protein homeostasis through Fbxo25 has a pivotal impact on cardiac development.
Beta-actin (show ACTB Proteins), physically interacts through its N-terminus with FBXO25 and is enriched in the FBXO25 nuclear compartments.
The cellular distribution of FBXO25 and its colocalization with some nuclear proteins is investigated by using immunochemical and biochemical approaches.
our findings reveal a novel mechanism for regulation of SCFFbox25-dependent Nkx2-5 (show NKX2-5 Proteins) and Tbx5 (show TBX5 Proteins) ubiquitination in cardiac development and provide a new insight into the regulatory mechanism of Nkx2-5 (show NKX2-5 Proteins) and Tbx5 (show TBX5 Proteins) transcriptional activity.
FBXO25 is a novel F-box protein (show FBXO30 Proteins) analogous to atrogin-1 (show FBXO32 Proteins), which is not involved in muscle atrophy.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
F-box protein 25
, F-box only protein 25
, f-box only protein 25-like
, F-box protein Fbx25