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FBXL19 encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. Additionally we are shipping FBXL19 Kits (12) and FBXL19 Proteins (3) and many more products for this protein.
Showing 10 out of 24 products:
Human Polyclonal FBXL19 Primary Antibody for WB - ABIN1537454
Wei, Mialki, Dong, Khoo, Mallampalli, Zhao, Zhao: A new mechanism of RhoA ubiquitination and degradation: Roles of SCF(FBXL19) E3 ligase and Erk2. in Biochimica et biophysica acta 2013
Show all 3 references for 1537454
Collectively these data unveil that FBXL19 functions as an antagonist of Rac3 (show RAC3 Antibodies) by regulating its stability and regulates the TGFbeta1 (show TGFB1 Antibodies)-induced E-cadherin (show CDH1 Antibodies) down-regulation.
SCF (show KITLG Antibodies)(FBXL19) targets RhoA (show RHOA Antibodies) for its disposal, a process regulated by Erk2 (show MAPK1 Antibodies).
Data indicate that overexpression of FBXL19 decreased both Rac1 active and inactive forms and significantly reduced cellular migration.
The fundamental observation was that FBXL19 attenuated IL-33 (show IL33 Antibodies)-mediated activity by removing ST2L (show TMED1 Antibodies), but not sST2 (show SSTR2 Antibodies) or IL-1R1, on the cell surface.
This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein binds to the transmembrane receptor ST2L and regulates its ubiquination and degradation. This protein has been linked to the regulation of pulmonary inflammation and psoriasis. Alternative splicing results in multiple transcript variants.
F-box/LRR-repeat protein 19
, F-box and leucine-rich repeat protein 19
, f-box/LRR-repeat protein 19-like
, jumonji C domain-containing histone demethylase 1C