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Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. Additionally we are shipping and and many more products for this protein.
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Human Polyclonal FBXW12 Primary Antibody for EIA, FACS - ABIN952293
Zeng, Gu, Li, Wang, Huang, Ye, Xu, Zhao, Ji, Ying, Xie, Mao: cDNA cloning and expression analysis of a novel human F-box domain containing gene. in Molecular biology reports 2004
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FBXW12 gene is deleted in approximately ten percent of the epithelial ovarian cancer cases studied; such deletions comprised either the FBXW12 promoter or the mRNA-encoding region.
FBXW12 functions as an E3 ligase constituent to ubiquitinate and degrade IL-22R (show IL22RA1 Antibodies) and that therapeutic FBXW12 inhibition may enhance IL-22 (show IL22 Antibodies) signaling and bolster mucosal host defense and infection containment.
FBXO35 gene had a ubiquitously low expression pattern in most human adult tissues. FBXO35 gene was found located in chromosome 3p21.
Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004
F-box and WD-40 domain protein 12
, F-box and WD-40 domain-containing protein 12
, F-box only protein 35
, F-box- and WD40-repeat-containing protein
, F-box/WD repeat-containing protein 12