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FRMPD2 encodes a peripheral membrane protein and is located in a region of chromosome 10q that contains a segmental duplication. Additionally we are shipping and many more products for this protein.
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These results provide novel insights into the molecular function of FRMPD2 and into the targeting mechanism of peripheral membrane proteins in polarized epithelial cells.
This gene encodes a peripheral membrane protein and is located in a region of chromosome 10q that contains a segmental duplication. This copy of the gene is full-length and is in the telomeric duplicated region. Two other more centromerically proximal copies of the gene are partial and may represent pseudogenes. This full-length gene appears to function in the establishment and maintenance of cell polarization. The protein is recruited to cell-cell junctions in an E-cadherin-dependent manner, and is selectively localized at the basolateral membrane in polarized epithelial cells. Alternative splicing results in multiple transcript variants.
FERM and PDZ domain containing 2
, FERM and PDZ domain-containing protein 2
, PDZ domain containing 5C
, PDZ domain-containing protein 4