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Transcription repressor. Additionally we are shipping FEZF2 Antibodies (43) and FEZF2 Kits (3) and many more products for this protein.
Showing 8 out of 8 products:
Fezf2 is important for early development of the posterior hypothalamus.
This study demonistrated that Fezf2 regulates multilineage neuronal differentiation through activating basic helix-loop-helix and homeodomain genes in the zebrafish ventral forebrain.
the feasibility of employing genomic SELEX to identify vertebrate transcription factor binding sites and target genes and reveal Fezf2 as a transcription activator
identify neurogenin 1 (show NEUROG1 Proteins) as a determinant of brain dopaminergic neurons and provide insights into how Tof/Fezl regulates the development of these clinically important neuronal types
Fezf1 (show FEZF1 Proteins) and Fezf2 accomplish both independent and redundant functions across diverse tissue and cell types. [Review]
FEZF2 expression has a role in cell proliferation and differentiation in adult neural stem cells.
overexpression of EZH2 (show EZH2 Proteins) was frequently detected in NPC (show NPC1 Proteins) tumors. Thus, we have identified FEZF2 as a novel 3p14.2 TSG (show TWSG1 Proteins) frequently inactivated by promoter methylation in NPC (show NPC1 Proteins), which functions as a repressor downregulating multiple oncogene (show RAB1A Proteins) expression
the feasibility of employing genomic SELEX to identify vertebrate transcription factor binding sites and target genes and reveal Fezf2 as a transcription activator and a candidate for evaluation in human microcephaly.
ZNF312 and other brain-layer biomarkers have area dependent expressions in the human fetal cortex.
Enhanced clinical mastitis resistance in Holsteins with a FEZL p.Gly105(12_13) polymorphism.
findings indicate a wider role for Fezf2 within gene expression networks that underpin the diversity of layer 5 cortical projection neurons.
Study shows that the transcription factor Fezf2 directly regulates various tissue-restricted antigens genes in medullary thymic epithelial cells independently of Aire (show AIRE Proteins). Mice lacking Fezf2 in mTECs displayed severe autoimmune symptoms, including the production of autoantibodies and inflammatory cell infiltration targeted to peripheral organs.
Satb2 (show SATB2 Proteins) and Fezf2 regulation promotes subcerebral projection neuron identity in the developing cerebral cortex
Characterized the activity of regulatory regions around the Fezf2 locus at stages of corticogenesis. Identified a promoter that was sufficient for expression in the cerebral cortex, and enhancers that drove reporter gene expression in forebrain domains.
Fezf2 is a selector gene able to regulate the expression of gene sets that collectively define mouse corticospinal motor neurons (CSMN).
Ectopic Fezf2 expression is sufficient to redirect the fate of subventricular zone stem cells.
Our findings establish a new, distinct physiological identity of Fezf2-expressing neurons within mature motor cortex.
These results identify Fezf2 radial glial cells as a multipotent neocortical progenitor and suggest that the existence, and molecular identity, of laminar-fate-restricted RGCs awaits further investigation.
findings reveal that SOX (show QSOX1 Proteins) transcription factors converge onto a cis (show CISH Proteins)-acting element of Fezf2 and form critical components of a regulatory network controlling the identity and connectivity of corticospinal neurons
Fezf2 controls the specification of telencephalic progenitors from mouse embryonic stem cell
Transcription repressor. Involved in the development of the forebrain region (By similarity).
fez family zinc finger protein 2
, zinc finger protein 312
, FEZ family zinc finger 2
, fez family zinc finger protein 1
, fez family zinc finger protein 2-like
, forebrain embryonic zinc finger-like protein 2
, forebrain embryonic zinc finger
, forebrain embryonic zinc-finger like
, too few
, zinc-finger protein