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FIP1L1 encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. Additionally we are shipping FIP1 Like 1 (S. Cerevisiae) Proteins (3) and many more products for this protein.
Showing 10 out of 34 products:
Chicken Polyclonal FIP1L1 Primary Antibody for WB - ABIN2776582
Zhao, Oberg, Rush, Fay, Lambkin, Schwartz: A 57-nucleotide upstream early polyadenylation element in human papillomavirus type 16 interacts with hFip1, CstF-64, hnRNP C1/C2, and polypyrimidine tract binding protein. in Journal of virology 2005
F604S exchange in FIP1L1-PDGFRA (show PDGFRA Antibodies) enhances FIP1L1-PDGFRA (show PDGFRA Antibodies) protein stability via SHP-2 (show PTPN11 Antibodies) and SRC (show SRC Antibodies) and is associated with kinase inhibitor resistance in hypereosinophilic syndrome and chronic eosinophilic leukemia.
FIP1L1 differentially contributes to the pathogenesis of distinct types of leukemia.
FP fusion gene favors secondary KIT mutations in MCs (show SMCP Antibodies) via growth and proliferation signals or that a yet unknown mechanism causes genomic instability with independent evolution of FP and KIT D816V
Oncostatin M (show OSM Antibodies) is a FIP1L1/PDGFRA (show PDGFRA Antibodies)-dependent mediator of cytokine production in chronic eosinophilic leukemia.
description of polycythemia vera (show IGF2BP3 Antibodies) concurrent with FIP1L1-PDGFRA (show PDGFRA Antibodies)-positive myeloproliferative neoplasm with eosinophilia [case report]
Data show that the cyclin-dependent kinase 7/9 inhibitor (CDK7/9 inhibitor) potently inhibits FIP1L1-PDGFRalpha-positive Bcr-Abl-positive chronic myeloid leukemia (CML) cells.
results strongly suggest that JAK2 (show JAK2 Antibodies) is activated by Fip1 (show RRAGA Antibodies)-like1 (FIP1L1)-platelet-derived growth factor receptor alpha (show PDGFRA Antibodies) (F/P) and is required for F/P stimulation of cellular proliferation and infiltration in chronic eosinophilic leukemia
Treatment with imatinib is associated with an excellent prognosis in FIP1L1-PDGFRA (show PDGFRA Antibodies)-positive chronic eosinophilic leukemia in first chronic phase
FIP1L1/PDGFRA (show PDGFRA Antibodies) fusion gene-positive myeloproliferative disorders with eosinophilia are discussed.
The hypereosinophilic syndrome may result from a novel fusion tyrosine kinase (show TXK Antibodies) - FIP1L1-PDGFRalpha - that is a consequence of an interstitial chromosomal deletion.
FIP1L1-PDGFRalpha activation requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent
This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
FIP1 like 1
, FIP1-like 1 protein
, pre-mRNA 3'-end-processing factor FIP1
, FIP1L1 cleavage and polyadenylation specific factor subunit
, factor interacting with PAP
, rearranged in hypereosinophilia