FIP1 Like 1 (S. Cerevisiae) (FIP1L1) ELISA Kits

FIP1L1 encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. Additionally we are shipping FIP1 Like 1 (S. Cerevisiae) Antibodies (40) and FIP1 Like 1 (S. Cerevisiae) Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human FIP1L1 FIP1L1 81608 Q6UN15
Anti-Rat FIP1L1 FIP1L1 289582 Q5U317
Anti-Mouse FIP1L1 FIP1L1 66899 Q9D824
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More ELISA Kits for FIP1 Like 1 (S. Cerevisiae) Interaction Partners

Human FIP1 Like 1 (S. Cerevisiae) (FIP1L1) interaction partners

  1. F604S exchange in FIP1L1-PDGFRA (show PDGFRA ELISA Kits) enhances FIP1L1-PDGFRA (show PDGFRA ELISA Kits) protein stability via SHP-2 (show PTPN11 ELISA Kits) and SRC (show SRC ELISA Kits) and is associated with kinase inhibitor resistance in hypereosinophilic syndrome and chronic eosinophilic leukemia.

  2. FIP1L1 differentially contributes to the pathogenesis of distinct types of leukemia.

  3. FP fusion gene favors secondary KIT mutations in MCs (show SMCP ELISA Kits) via growth and proliferation signals or that a yet unknown mechanism causes genomic instability with independent evolution of FP and KIT D816V

  4. Oncostatin M (show OSM ELISA Kits) is a FIP1L1/PDGFRA (show PDGFRA ELISA Kits)-dependent mediator of cytokine production in chronic eosinophilic leukemia.

  5. description of polycythemia vera (show IGF2BP3 ELISA Kits) concurrent with FIP1L1-PDGFRA (show PDGFRA ELISA Kits)-positive myeloproliferative neoplasm with eosinophilia [case report]

  6. Data show that the cyclin-dependent kinase 7/9 inhibitor (CDK7/9 inhibitor) potently inhibits FIP1L1-PDGFRalpha-positive Bcr-Abl-positive chronic myeloid leukemia (CML) cells.

  7. results strongly suggest that JAK2 (show JAK2 ELISA Kits) is activated by Fip1 (show RRAGA ELISA Kits)-like1 (FIP1L1)-platelet-derived growth factor receptor alpha (show PDGFRA ELISA Kits) (F/P) and is required for F/P stimulation of cellular proliferation and infiltration in chronic eosinophilic leukemia

  8. Treatment with imatinib is associated with an excellent prognosis in FIP1L1-PDGFRA (show PDGFRA ELISA Kits)-positive chronic eosinophilic leukemia in first chronic phase

  9. FIP1L1/PDGFRA (show PDGFRA ELISA Kits) fusion gene-positive myeloproliferative disorders with eosinophilia are discussed.

  10. The hypereosinophilic syndrome may result from a novel fusion tyrosine kinase (show TXK ELISA Kits) - FIP1L1-PDGFRalpha - that is a consequence of an interstitial chromosomal deletion.

Mouse (Murine) FIP1 Like 1 (S. Cerevisiae) (FIP1L1) interaction partners

  1. FIP1L1-PDGFRalpha activation requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent

FIP1 Like 1 (S. Cerevisiae) (FIP1L1) Antigen Profile

Antigen Summary

This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with FIP1L1

  • factor interacting with PAPOLA and CPSF1 (fip1l1) antibody
  • FIP1 like 1 (S. cerevisiae) (FIP1L1) antibody
  • factor interacting with PAPOLA and CPSF1 (FIP1L1) antibody
  • factor interacting with PAPOLA and CPSF1 (Fip1l1) antibody
  • FIP1 like 1 (S. cerevisiae) (Fip1l1) antibody
  • FIP1 like 1b (S. cerevisiae) (fip1l1b) antibody
  • 1300019H17Rik antibody
  • FIP1 antibody
  • fip1l1 antibody
  • hFip1 antibody
  • Rhe antibody
  • Rje antibody
  • wu:fd36f11 antibody
  • zgc:103421 antibody

Protein level used designations for FIP1L1

FIP1 like 1 , FIP1-like 1 protein , pre-mRNA 3'-end-processing factor FIP1 , FIP1L1 cleavage and polyadenylation specific factor subunit , factor interacting with PAP , rearranged in hypereosinophilia

733481 Xenopus (Silurana) tropicalis
100172699 Pongo abelii
81608 Homo sapiens
494780 Xenopus laevis
289582 Rattus norvegicus
422754 Gallus gallus
612980 Canis lupus familiaris
100138550 Bos taurus
66899 Mus musculus
450021 Danio rerio
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