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FK506 Binding Protein 1a Proteins (FKBP1A)

The protein encoded by FKBP1A is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Additionally we are shipping FK506 Binding Protein 1a Antibodies (18) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse FKBP1A FKBP1A 14225 P26883
Rat FKBP1A FKBP1A 25639 Q62658
FKBP1A 2280 P62942
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Top FK506 Binding Protein 1a Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 11 to 13 Days
$563.20
Details
HOST_Escherichia coli (E. coli) Cow His tag 100 μg Log in to see 11 to 13 Days
$774.40
Details
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 2 to 3 Days
$137.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 6 to 7 Days
$244.68
Details

FKBP1A Proteins by Origin and Source

Origin Expressed in Conjugate
Human

More Proteins for FK506 Binding Protein 1a (FKBP1A) Interaction Partners

Mouse (Murine) FK506 Binding Protein 1a (FKBP1A) interaction partners

  1. We demonstrate that FKBP12 and its ligands impact multiple aspects of muscle function.

  2. Fkbp1a-mediated regulation of Notch1 (show NOTCH1 Proteins) plays an important role in intercellular communication between endocardium and myocardium.

  3. FKBP12 is critically important in regulating trans-sarcolemmal ionic currents, predominately the voltage-gated Na+ current, I Na

  4. the impact of simulated ischemia and reperfusion on expression of the calcium handling proteins FKBP12 and FKBP12.6 (show FKBP1B Proteins), and intracellular calcium dynamics was investigated.

  5. Data show that deletion of FKBP12 increased transforming growth factor-beta receptor activation and SMAD2 (show SMAD2 Proteins)/3 signaling.

  6. FKBP12 is a critical regulator of I(Na) and is important for cardiac arrhythmogenic physiology

  7. a trimeric-interaction among calcineurin (show PPP3CA Proteins), FKBP12, and RyR is important for the regulation of the RyR channel activity and may play an important role in the Ca(2 (show CA2 Proteins)+) signaling of muscle contraction and relaxation

  8. FKBP12 binding to RyR1 enhances the gain of skeletal muscle excitation-contraction coupling

  9. used systemic gene transfer in tumor-bearing mice to identify novel antiinvasive and antimetastatic functions for Fkbp8 (show FKBP8 Proteins), and subsequently for Fkbp1a

  10. FKBP12 deficiency alters both orthograde and retrograde coupling between the L-type Ca2+ channel and RyR1 and the consequences of these changes depend on muscle type and activity

Human FK506 Binding Protein 1a (FKBP1A) interaction partners

  1. Findings indicate that mutant huntingtin (show HTT Proteins) (mHTT) aggregates can be transformed into benign species by isomerase FKBP12.

  2. RyRs have been identified as important targets of FKBP12 and FKBP12.6 (show FKBP1B Proteins), members of the immunophilin family

  3. How phosphorylation of RyR affects channel activity and whether proteins such as the FK-506 binding proteins (FKBP12 and FKBP12.6 (show FKBP1B Proteins)) are involved in heart failure

  4. Ultra-fast Shape Recognition with Atom Types--the discovery of novel bioactive small molecular scaffolds for FKBP12 and 11betaHSD1.

  5. Selectivity within the FKBP (show FKBP7 Proteins) family, in particular selective inhibition of FKBP12 or FKBP51 (show FKBP4 Proteins), is possible. FKBP51 (show FKBP4 Proteins) is a pharmacologically tractable target for stress-related disorders.

  6. peptidyl prolyl cis-trans isomerase (show PPIL1 Proteins) activity of FKBP12 probably plays a role in inhibition of receptor phosphorylation.

  7. FKBP12 inhibits RyR1 and FKBP12 E31Q/D32N/W59F mutant activates RyR1 in vitro.

  8. FKBP12 regulates the localization and processing of amyloid precursor protein (show APP Proteins) in human cell lines.

  9. Enhanced plasticity in the active site of FKBP12.6 (show FKBP1B Proteins) is likely to contribute to marked attenuation in the spatial extent of the residues that exhibit doubling of their amide resonances compared with those of the homologous FKBP12.

  10. the structural basis of the slow resonance doubling transition of FKBP12 and the more rapid conformational linebroadening transition in the 80's loop to gain insight into how these effects are propagated through the protein structure

FK506 Binding Protein 1a (FKBP1A) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed.

Gene names and symbols associated with FKBP1A

  • FK506 binding protein 1a (Fkbp1a)
  • FK506 binding protein 1A, 12kDa (FKBP1A)
  • FK506 binding protein 1A, 12kDa pseudogene 4 (FKBP1AP4)
  • 12kDa protein
  • Fkbp protein
  • FKBP-1A protein
  • FKBP-12 protein
  • FKBP1 protein
  • FKBP1P4 protein
  • Fkbp2 protein
  • FKBP12 protein
  • FKBP12-T1 protein
  • FKBP12-T2 protein
  • mFKBP1 protein
  • mFKBP12 protein
  • PKC12 protein
  • PKCI2 protein
  • PPIASE protein

Protein level used designations for FKBP1A

12 kDa FK506-binding protein , 12 kDa FKBP , FK506 Binding Protein12-T1 , FK506 binding protein12 , FK506 binding protein12-T2 , FK506-binding protein 1A , FKBP-12 , FKBP-1A , FKBP12-Exip3 , PPIase FKBP1A , calstabin-1 , immunophilin FKBP12 , peptidyl-prolyl cis-trans isomerase FKBP1A , rotamase , FK506 binding protein 2 (13 kDa) , FK506-binding protein 1 (12kD) , FK506-binding protein 1a , FK506-binding protein 1 , FK506-binding protein 12 , FK506-binding protein 1A (12kD) , FK506-binding protein, T-cell, 12-kD , calstabin 1 , protein kinase C inhibitor 2

GENE ID SPECIES
14225 Mus musculus
25639 Rattus norvegicus
2280 Homo sapiens
2285 Homo sapiens
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