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FK506 Binding Protein 4, 59kDa Proteins (FKBP4)

The protein encoded by FKBP4 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Additionally we are shipping FK506 Binding Protein 4, 59kDa Antibodies (163) and FK506 Binding Protein 4, 59kDa Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FKBP4 14228 P30416
FKBP4 260321 Q9QVC8
FKBP4 2288 Q02790
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Top FK506 Binding Protein 4, 59kDa Proteins at antibodies-online.com

Showing 10 out of 20 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 2 to 3 Days
$320.25
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$242.00
Details
Yeast Rhizopus oryzae His tag   1 mg Log in to see 56 to 66 Days
$3,050.67
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,287.17
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$3,287.17
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,290.83
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 5 Days
$154.00
Details

FKBP4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human , ,
,

Top referenced FK506 Binding Protein 4, 59kDa Proteins

  1. Human FKBP4 Protein expressed in Escherichia coli (E. coli) - ABIN666763 : Ma, Bai, Guo, Jiang: The switch I region of Rheb is critical for its interaction with FKBP38. in The Journal of biological chemistry 2008 (PubMed)
    Show all 2 references for ABIN666763

  2. Human FKBP4 Protein expressed in Wheat germ - ABIN1354126 : Ardi, Alexander, Johnson, McAlpine: Macrocycles that inhibit the binding between heat shock protein 90 and TPR-containing proteins. in ACS chemical biology 2011 (PubMed)

More Proteins for FK506 Binding Protein 4, 59kDa (FKBP4) Interaction Partners

Mouse (Murine) FK506 Binding Protein 4, 59kDa (FKBP4) interaction partners

  1. identify a novel steroid-responsive FKBP52-dependent pathway suppressing the expression and activity of tryptophan-2,3-dioxygenase (show TDO2 Proteins)

  2. study identifies Fkbp4 and Fkbp5 as novel components of the Ago2 RISC loading complex

  3. FKBP52 is not involved in all branches of GR signaling, but rather acts in a gene-specific manner to regulate GR transcriptional activation.

  4. FKBP52 regulates androgen receptor (show AR Proteins) function through the BF3 surface.

  5. Findings suggest that Fkbp52 deficiency diminishes the threshold against OS by reducing PRDX6 (show PRDX6 Proteins) levels.

  6. Fkbp52 is an important molecular regulator in the androgen-mediated pathway of urethra morphogenesis.

  7. Data propose a model in which FKBP52 loss reduces GR control of gluconeogenesis, predisposing the liver to steatosis under HF-diet conditions attributable to a shunting of metabolism from glucose production to lipogenesis.

  8. a Hoxa10 (show HOXA10 Proteins)-FKBP52 signaling axis is critical to uterine receptivity and implantation

  9. FKBP52 is an AR folding factor that has critically important physiological roles in some male reproductive tissues

  10. Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation.

Human FK506 Binding Protein 4, 59kDa (FKBP4) interaction partners

  1. The Hsp90 (show HSP90 Proteins)-associated FKBP52 cochaperone has become increasingly associated with aberrant steroid hormone receptor (show NR4A1 Proteins) signaling in disease. [review]

  2. The capacity FKBP52 to oligomerize Tau is not linked to its peptidyl-prolyl isomerase activity.

  3. FKBP52 and beta-catenin (show CTNNB1 Proteins) interact directly in vitro. FKBP52 promotes beta-catenin (show CTNNB1 Proteins) interaction with androgen receptor (show AR Proteins) signaling.

  4. FKBP4 was not differentially expressed in PTSD patients with low HPA (show HPSE Proteins) axis reactivity compared to PTSD patients with high HPA (show HPSE Proteins) axis reactivity.

  5. FKBP51 is the major target accounting for the neuritotrophic effect of neuroimmunophilin ligands. Selectivity against the homolog FKBP52 is essential for optimal neuritotrophic efficacy.

  6. identify a novel steroid-responsive FKBP52-dependent pathway suppressing the expression and activity of tryptophan-2,3-dioxygenase (show TDO2 Proteins)

  7. FKBP52 seems to be disrupted in preeclampsia and intrauterine growth restriction pregnancies

  8. The biological action of NF-kappaB (show NFKB1 Proteins) in different cell types could be positively regulated by a high FKBP52/FKBP51 expression ratio.

  9. Molecular chaperone (show HSP90AA1 Proteins) activity and biological regulatory actions of the TPR-domain immunophilins FKBP51 and FKBP52

  10. Despite their substantial structural similarity, in both the beta3 bulge and the beta4-beta5 loop, the FK1 domain of FKBP51 undergoes significantly populated conformational transitions that appear to be suppressed in FKBP52.

FK506 Binding Protein 4, 59kDa (FKBP4) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene.

Gene names and symbols associated with FKBP4

  • FK506 binding protein 4, 59kDa (FKBP4)
  • FK506 binding protein 4, 59kDa (fkbp4)
  • FK506 binding protein 4, 59kDa (LOC100229761)
  • FK506 binding protein 4 (fkbp4)
  • FK506 binding protein 4 (Fkbp4)
  • 59kDa protein
  • AL022792 protein
  • AW208983 protein
  • FKBP-4 protein
  • FKBP-52 protein
  • FKBP51 protein
  • FKBP52 protein
  • FKBP59 protein
  • FKPB52 protein
  • HBI protein
  • Hsp56 protein
  • MGC81078 protein
  • p52 protein
  • P59 protein
  • PPIase protein
  • wu:fb34f09 protein

Protein level used designations for FKBP4

peptidyl-prolyl cis-trans isomerase FKBP4 , FK506-binding protein 4 , FK506 binding protein 4, 59kDa , peptidyl-prolyl cis-trans isomerase FKBP4-like , 52 kDa FK506-binding protein , 52 kDa FKBP , 59 kDa immunophilin , FKBP59 , HBI , HSP-binding immunophilin , PPIase FKBP4 , immunophilin FKBP52 , rotamase , FK506 binding protein 52 , FKBP52 protein , 51 kDa FK506-binding protein , FK506-binding protein 4 (59kD) , HSP binding immunophilin , T-cell FK506-binding protein, 59kD , peptidylprolyl cis-trans isomerase , hsp90 binding protein , p59 protein

GENE ID SPECIES
418261 Gallus gallus
451748 Pan troglodytes
708481 Macaca mulatta
414546 Xenopus laevis
100016812 Monodelphis domestica
100229761 Taeniopygia guttata
100379681 Xenopus (Silurana) tropicalis
100411442 Callithrix jacchus
100449665 Pongo abelii
100476786 Ailuropoda melanoleuca
321795 Danio rerio
100195395 Salmo salar
14228 Mus musculus
260321 Rattus norvegicus
2288 Homo sapiens
100009148 Oryctolagus cuniculus
477726 Canis lupus familiaris
100337672 Sus scrofa
508535 Bos taurus
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