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FK506 Binding Protein 5 Proteins (FKBP5)

The protein encoded by FKBP5 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Additionally we are shipping FKBP5 Antibodies (100) and FKBP5 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FKBP5 2289 Q13451
FKBP5 14229 Q64378
Rat FKBP5 FKBP5 361810  
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Top FKBP5 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 11 to 13 Days
$823.90
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$704.00
Details
Yeast Rhizopus oryzae His tag   1 mg Log in to see 56 to 66 Days
$3,059.83
Details
Yeast REACT_Green monkey His tag   1 mg Log in to see 56 to 66 Days
$3,285.33
Details
Yeast Saguinus oedipus His tag   1 mg Log in to see 56 to 66 Days
$3,285.33
Details
Yeast Primates His tag   1 mg Log in to see 56 to 66 Days
$3,285.33
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$889.07
Details

FKBP5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Top referenced FKBP5 Proteins

  1. Human FKBP5 Protein expressed in Wheat germ - ABIN1354130 : Horibe, Kohno, Haramoto, Ohara, Kawakami: Designed hybrid TPR peptide targeting Hsp90 as a novel anticancer agent. in Journal of translational medicine 2011 (PubMed)

More Proteins for FK506 Binding Protein 5 (FKBP5) Interaction Partners

Human FK506 Binding Protein 5 (FKBP5) interaction partners

  1. FKBP51 (show FKBP4 Proteins) appears to be a common denominator to epithelial to mesenchymal transition, cancer stemness and drug resistance, in melanoma. [review]

  2. Clinical evidence for the role of the glucocorticoid receptor (show NR3C1 Proteins)-GRFKBP51 system in mental disorders is presented here. [review]

  3. Interaction effect between childhood abuse and the FKBP5 gene rs1360780 SNP on positive psychotic experiences.

  4. 3 FKBP5 SNPs (rs3800373, rs7753746, and rs9380526) predicted chronic postconcussive symptom severity. Similar effect sizes were observed for the minor alleles of rs7753746 and rs9380526.

  5. This review illustrates how FKBP5 genetic variants confer risk for stress-related disorders.

  6. Results show that allelic variants in the rs1360780 region of the FKBP5 gene are associated with differences in regional brain activity during evaluation of emotional stimuli in patients with Major Depressive Disorder

  7. Results indicate that genetic variation in FKBP5 influences the risk of anxiety and/or depressive disorders in preschool age by altering the sensitivity to the deleterious effects of mild to moderate adverse events

  8. Study indicates that genetic alterations in FKBP5 may influence vulnerability to suicide

  9. These findings point to the minor alleles of the FKBP5 polymorphism being a risk factor for development of intrusive memories, possibly as a result of impaired glucocorticoid receptor (show NR3C1 Proteins) sensitivity.

  10. the abundance of BDNF (show BDNF Proteins) positively correlated and phosphorylated DNMT1 (show DNMT1 Proteins) inversely correlated with that of FKBP51 (show FKBP4 Proteins) in cells

Mouse (Murine) FK506 Binding Protein 5 (FKBP5) interaction partners

  1. We discovered that the suggested psychiatric risk factor FK506 binding protein 51 (FKBP51) increases phosphorylation of GSK3beta at serine 9 (pGSK3beta(S9)).

  2. Results suggest that regulation of Fkbp5 mRNA expression via DNA methylation (show HELLS Proteins), and its subsequent regulation of glucocorticoid receptor (show NR3C1 Proteins) sensitivity may be implicated in the molecular mechanisms of fear retention and extinciton

  3. the abundance of BDNF (show BDNF Proteins) positively correlated and phosphorylated DNMT1 (show DNMT1 Proteins) inversely correlated with that of FKBP51 in cells

  4. FKBP5 associates with BECN1 (show BECN1 Proteins), changes its phosphorylation and protein levels and enhances markers of autophagy and autophagic flux

  5. Aged animals display elevated FKBP51 levels, which contribute to impaired resiliency to depressive-like behaviors through impaired glucocorticoid signaling, a phenotype that is abrogated in FKBP5-/- mice.

  6. Overexpression of FKBP51 in the amygdala resulted in increased anxiety-related behavior.

  7. the stress response, as well as the effects of antidepressants on behavior and autophagic markers, depends on FKBP51.

  8. FKBP51 is a key regulator of adipogenesis via the Akt (show AKT1 Proteins)-p38 (show CRK Proteins) pathway.

  9. FKBP51 loss reciprocally regulates glucocorticoid receptor alpha (show NR3C1 Proteins) and PPARgamma (show PPARG Proteins) via 2 complementary mechanisms.

  10. In mice, the absence of the Fkbp5 gene enhances sensitivity to alcohol withdrawal.

FKBP5 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with FKBP5

  • FK506 binding protein 5 (FKBP5)
  • FK506 binding protein 5 (fkbp5)
  • FK506 binding protein 5 (Fkbp5)
  • AIG6 protein
  • D17Ertd592e protein
  • Dit1 protein
  • FKBP-5 protein
  • FKBP5 protein
  • FKBP51 protein
  • FKBP54 protein
  • P54 protein
  • PPIase protein
  • Ptg-10 protein
  • si:zc263a23.8 protein
  • wu:fc31g11 protein
  • wu:fl87b03 protein
  • zgc:64082 protein

Protein level used designations for FKBP5

FK506 binding protein 5 , FK506-binding protein 5 , PPIase FKBP5 , peptidyl-prolyl cis-trans isomerase FKBP5 , rotamase , 51 kDa FK506-binding protein 5 , 51 kDa FKBP , 54 kDa progesterone receptor-associated immunophilin , FF1 antigen , FKBP-5 , FKBP-51 , HSP90-binding immunophilin , T-cell FK506-binding protein , androgen-regulated protein 6 , peptidylprolyl cis-trans isomerase , 51 kDa FK506-binding protein

GENE ID SPECIES
462639 Pan troglodytes
100171536 Pongo abelii
100544523 Meleagris gallopavo
100551895 Anolis carolinensis
100591277 Nomascus leucogenys
2289 Homo sapiens
14229 Mus musculus
361810 Rattus norvegicus
368924 Danio rerio
421186 Gallus gallus
481759 Canis lupus familiaris
100155423 Sus scrofa
535704 Bos taurus
100339155 Oryctolagus cuniculus
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