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The protein encoded by FKBP5 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Additionally we are shipping FKBP5 Proteins (13) and FKBP5 Kits (11) and many more products for this protein.
Showing 10 out of 121 products:
Dog (Canine) Monoclonal FKBP5 Primary Antibody for ICC, IF - ABIN361795
Cheung-Flynn, Roberts, Riggs, Smith: C-terminal sequences outside the tetratricopeptide repeat domain of FKBP51 and FKBP52 cause differential binding to Hsp90. in The Journal of biological chemistry 2003
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Human Polyclonal FKBP5 Primary Antibody for IF, IHC (p) - ABIN515669
Romano, Staibano, Greco, Brunetti, Nappo, Ilardi, Martinelli, Sorrentino, Di Pace, Mascolo, Bisogni, Scalvenzi, Alfano, Romano: FK506 binding protein 51 positively regulates melanoma stemness and metastatic potential. in Cell death & disease 2013
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Human Polyclonal FKBP5 Primary Antibody for ICC, IF - ABIN261155
Romano, DAngelillo, Staibano, Simeone, DArrigo, Ascierto, Scalvenzi, Mascolo, Ilardi, Merolla, Jovarauskaite, Romano: Immunomodulatory pathways regulate expression of a spliced FKBP51 isoform in lymphocytes of melanoma patients. in Pigment cell & melanoma research 2015
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Cow (Bovine) Polyclonal FKBP5 Primary Antibody for IHC, WB - ABIN2785846
Lekman, Laje, Charney, Rush, Wilson, Sorant, Lipsky, Wisniewski, Manji, McMahon, Paddock: The FKBP5-gene in depression and treatment response--an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Cohort. in Biological psychiatry 2008
Human Monoclonal FKBP5 Primary Antibody for ELISA, WB - ABIN560908
van Lierop, Alkema, Laskewitz, Dijkema, van der Maaden, Smit, Plate, Conti, Jans, Timmers, van Boeckel, Lusher, McGuire, van Schaik, de Vlieg, Smeets, Hofstra, Boots, van Duin, Ingelse, Schoonen et al.: Org 214007-0: a novel non-steroidal selective glucocorticoid receptor modulator with full anti-inflammatory properties and improved therapeutic index. ... in PLoS ONE 2012
we found no effect of early life trauma on heavy drinking in rs1360780*T-allele carriers, rs1360780*C homozygotes exposed to early life trauma had a lower probability of heavy drinking compared to rs1360780*C homozygotes not exposed to early life trauma (P < 0.01). There exists a developmental period of susceptibility to stress that is moderated by FKBP5 genotype.
LIF (show LIF Antibodies) and FKBP51 (show FKBP4 Antibodies) expression in epithelial cells were the most interesting markers of Airway epithelial cells dysfunction/response to corticosteroid treatment.
The data of this study show a significant increase in DNA methylation (show HELLS Antibodies) of FKBP5 in peripheral blood mononuclear cells of major depressive disorder patients.
Knockdown of FKBP51 (show FKBP4 Antibodies) alleviates neuropathic pain via inhibiting the NF-kappaB (show NFKB1 Antibodies) signaling in chronic constriction injury rat model.
we sought to extend prior GxE findings by examining the relation of four FKBP5 SNPs (rs9296158, rs3800373, rs1360780, rs947008), childhood abuse, and lifetime PTSD symptom severity. Results revealed that the four FKBP5 SNPs were associated with PTSD symptom severity in both samples . SNP rs9470080 in the main sample, and all four SNPs in the replication sample interacted with childhood abuse to predict PTSD severity
Findings suggest that posttraumatic stress disorder (PTSD) phenotypes may be characterized by differences in intracellular signaling transduction processes. The associations of expression of GRalpha and FKBP5 in the glucocorticoid (GC) high-sensitive PTSD subgroup may thereby reflect physiological adaptation to preserve immune-relevant GC signaling.
Associations between FKBP5 genotype and neurodevelopment; potential interaction between FKBP5 genotype and stress experiences (NICU) in preterm infants.
The main finding in this study is that Holocaust survivors and their offspring have methylation changes on the same site in a functional intronic region of the FKBP5 gene, a GR-binding sequence in intron 7.
FKBP51 (show FKBP4 Antibodies) improves the ability of stromal androgen receptor (show AR Antibodies) to predict prostate cancer-specific mortality.
the interaction between bullying and the FKBP5 haplotype was associated with positive, but not negative, psychotic-like experiences, paranoia, and negative affect
Findings indicate a role of FK506 binding protein 5 (FKBP5) in hypoxia-regulated adipogenesis.
important regulator of PPARgamma (show PPARG Antibodies) in white adipose tissue
FKBP5 might increase muscle mass through the enhancements of muscle protein synthesis and myotube differentiation as well as an inhibition of muscle protein degradation in mice
findings show that miR (show MLXIP Antibodies)-511 is a functional regulator of FKBP5 and can contribute to neuronal differentiation.
These results suggest that the association between FKBP5 and alcohol consumption is conserved in both mice and humans.
We discovered that the suggested psychiatric risk factor FK506 binding protein (show FKBPL Antibodies) 51 (FKBP51) increases phosphorylation of GSK3beta (show GSK3b Antibodies) at serine 9 (pGSK3beta(S9)).
Results suggest that regulation of Fkbp5 mRNA expression via DNA methylation (show HELLS Antibodies), and its subsequent regulation of glucocorticoid receptor (show NR3C1 Antibodies) sensitivity may be implicated in the molecular mechanisms of fear retention and extinciton
the abundance of BDNF (show BDNF Antibodies) positively correlated and phosphorylated DNMT1 (show DNMT1 Antibodies) inversely correlated with that of FKBP51 in cells
FKBP5 associates with BECN1 (show BECN1 Antibodies), changes its phosphorylation and protein levels and enhances markers of autophagy and autophagic flux
Aged animals display elevated FKBP51 levels, which contribute to impaired resiliency to depressive-like behaviors through impaired glucocorticoid signaling, a phenotype that is abrogated in FKBP5-/- mice.
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.
FK506 binding protein 5
, FK506-binding protein 5
, PPIase FKBP5
, peptidyl-prolyl cis-trans isomerase FKBP5
, 51 kDa FK506-binding protein 5
, 51 kDa FKBP
, 54 kDa progesterone receptor-associated immunophilin
, FF1 antigen
, HSP90-binding immunophilin
, T-cell FK506-binding protein
, androgen-regulated protein 6
, peptidylprolyl cis-trans isomerase
, 51 kDa FK506-binding protein