FK506 Binding Protein 5 Proteins (FKBP5)

The protein encoded by FKBP5 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Additionally we are shipping FKBP5 Antibodies (121) and FKBP5 Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FKBP5 2289 Q13451
FKBP5 14229 Q64378
Rat FKBP5 FKBP5 361810  
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Top FKBP5 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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HOST_Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 15 to 18 Days
$749.00
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see 10 to 12 Days
$229.85
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HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
$640.00
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Yeast Rhizopus oryzae His tag   1 mg Log in to see 60 to 71 Days
$3,059.83
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Yeast REACT_Green monkey His tag   1 mg Log in to see 60 to 71 Days
$3,285.33
Details
Yeast Saguinus oedipus His tag   1 mg Log in to see 60 to 71 Days
$3,285.33
Details

FKBP5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine) ,

Top referenced FKBP5 Proteins

  1. Human FKBP5 Protein expressed in Wheat germ - ABIN1354130 : Horibe, Kohno, Haramoto, Ohara, Kawakami: Designed hybrid TPR peptide targeting Hsp90 as a novel anticancer agent. in Journal of translational medicine 2011 (PubMed)

More Proteins for FK506 Binding Protein 5 (FKBP5) Interaction Partners

Human FK506 Binding Protein 5 (FKBP5) interaction partners

  1. we sought to extend prior GxE findings by examining the relation of four FKBP5 SNPs (rs9296158, rs3800373, rs1360780, rs947008), childhood abuse, and lifetime PTSD symptom severity. Results revealed that the four FKBP5 SNPs were associated with PTSD symptom severity in both samples . SNP rs9470080 in the main sample, and all four SNPs in the replication sample interacted with childhood abuse to predict PTSD severity

  2. Findings suggest that posttraumatic stress disorder (PTSD) phenotypes may be characterized by differences in intracellular signaling transduction processes. The associations of expression of GRalpha and FKBP5 in the glucocorticoid (GC) high-sensitive PTSD subgroup may thereby reflect physiological adaptation to preserve immune-relevant GC signaling.

  3. Associations between FKBP5 genotype and neurodevelopment; potential interaction between FKBP5 genotype and stress experiences (NICU) in preterm infants.

  4. The main finding in this study is that Holocaust survivors and their offspring have methylation changes on the same site in a functional intronic region of the FKBP5 gene, a GR-binding sequence in intron 7.

  5. FKBP51 (show FKBP4 Proteins) improves the ability of stromal androgen receptor (show AR Proteins) to predict prostate cancer-specific mortality.

  6. the interaction between bullying and the FKBP5 haplotype was associated with positive, but not negative, psychotic-like experiences, paranoia, and negative affect

  7. FKBP5 methylation moderates the associations of FKBP5 genotype and resistant attachment with cortisol reactivity.

  8. Specific variations in FKBP5 gene increased the risk of attempted suicide.

  9. FKBP5 variations in combination early life stress predict more pronounced depressive symptoms in midlife.

  10. Our results confirm that the rs1360780 locus alters FKBP5 expression and further that in trans-fashion this locus affects the expression of other glucocorticoid-regulated genes after a glucocorticoid challenge. The CT exposure appears to be essential for trans-effects of rs1360780 on glucocorticoid-regulated genes.

Mouse (Murine) FK506 Binding Protein 5 (FKBP5) interaction partners

  1. Findings indicate a role of FK506 binding protein 5 (FKBP5) in hypoxia-regulated adipogenesis.

  2. important regulator of PPARgamma (show PPARG Proteins) in white adipose tissue

  3. FKBP5 might increase muscle mass through the enhancements of muscle protein synthesis and myotube differentiation as well as an inhibition of muscle protein degradation in mice

  4. findings show that miR (show MLXIP Proteins)-511 is a functional regulator of FKBP5 and can contribute to neuronal differentiation.

  5. These results suggest that the association between FKBP5 and alcohol consumption is conserved in both mice and humans.

  6. We discovered that the suggested psychiatric risk factor FK506 binding protein 51 (FKBP51) increases phosphorylation of GSK3beta at serine 9 (pGSK3beta(S9)).

  7. Results suggest that regulation of Fkbp5 mRNA expression via DNA methylation (show HELLS Proteins), and its subsequent regulation of glucocorticoid receptor (show NR3C1 Proteins) sensitivity may be implicated in the molecular mechanisms of fear retention and extinciton

  8. the abundance of BDNF (show BDNF Proteins) positively correlated and phosphorylated DNMT1 (show DNMT1 Proteins) inversely correlated with that of FKBP51 in cells

  9. FKBP5 associates with BECN1 (show BECN1 Proteins), changes its phosphorylation and protein levels and enhances markers of autophagy and autophagic flux

  10. Aged animals display elevated FKBP51 levels, which contribute to impaired resiliency to depressive-like behaviors through impaired glucocorticoid signaling, a phenotype that is abrogated in FKBP5-/- mice.

FKBP5 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with FKBP5

  • FK506 binding protein 5 (FKBP5)
  • FK506 binding protein 5 (fkbp5)
  • FK506 binding protein 5 (Fkbp5)
  • AIG6 protein
  • D17Ertd592e protein
  • Dit1 protein
  • FKBP-5 protein
  • FKBP5 protein
  • FKBP51 protein
  • FKBP54 protein
  • P54 protein
  • PPIase protein
  • Ptg-10 protein
  • si:zc263a23.8 protein
  • wu:fc31g11 protein
  • wu:fl87b03 protein
  • zgc:64082 protein

Protein level used designations for FKBP5

FK506 binding protein 5 , FK506-binding protein 5 , PPIase FKBP5 , peptidyl-prolyl cis-trans isomerase FKBP5 , rotamase , 51 kDa FK506-binding protein 5 , 51 kDa FKBP , 54 kDa progesterone receptor-associated immunophilin , FF1 antigen , FKBP-5 , FKBP-51 , HSP90-binding immunophilin , T-cell FK506-binding protein , androgen-regulated protein 6 , peptidylprolyl cis-trans isomerase , 51 kDa FK506-binding protein

GENE ID SPECIES
462639 Pan troglodytes
100171536 Pongo abelii
100544523 Meleagris gallopavo
100551895 Anolis carolinensis
100591277 Nomascus leucogenys
2289 Homo sapiens
14229 Mus musculus
361810 Rattus norvegicus
368924 Danio rerio
421186 Gallus gallus
481759 Canis lupus familiaris
100155423 Sus scrofa
535704 Bos taurus
100339155 Oryctolagus cuniculus
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