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anti-FRAS1 Related Extracellular Matrix 1 (FREM1) Antibodies

FREM1 encodes a basement membrane protein that may play a role in craniofacial and renal development. Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FREM1 158326 Q5H8C1
FREM1 298185  
FREM1 329872 Q684R7
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Top anti-FRAS1 Related Extracellular Matrix 1 Antibodies at antibodies-online.com

Showing 10 out of 26 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IF, WB Immunocytochemistry of FREM1 in K562 cells with FREM1 antibody at 20 μg/ml. Western blot analysis of FREM1 in K562 cell lysate with FREM1 antibody at (A) 0.5 and (B) 1μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated ICC, IHC (p), ELISA, WB Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated EIA, IF, IHC (p), WB Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated ICC, IHC (p), ELISA, WB 50 μg Log in to see 11 to 13 Days
$541.80
Details
Human Rabbit Un-conjugated ICC, ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$330.00
Details
Human Rabbit Alexa Fluor 647 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Biotin IHC (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

FREM1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-FRAS1 Related Extracellular Matrix 1 Antibodies

  1. Human Polyclonal FREM1 Primary Antibody for EIA, IF - ABIN783634 : Smyth, Du, Taylor, Justice, Beutler, Jackson: The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis. in Proceedings of the National Academy of Sciences of the United States of America 2004 (PubMed)

More Antibodies against FRAS1 Related Extracellular Matrix 1 Interaction Partners

Human FRAS1 Related Extracellular Matrix 1 (FREM1) interaction partners

  1. In 15 of 590 families, we identified recessive mutations in the genes FRAS1 (show FRAS1 Antibodies), FREM2 (show FREM2 Antibodies), GRIP1 (show NCOA2 Antibodies), FREM1, ITGA8, and GREM1 (show GREM1 Antibodies), all of which function in the interaction of the ureteric bud and the metanephric mesenchyme.

  2. Disruption of the FREM1 gene can produce a spectrum of clinical manifestations encompassing the previously described MOTA and BNAR syndromes.

  3. We conclude that FREM1 plays a critical role in the development of the diaphragm and that FREM1 deficiency can cause CDH (show CHDH Antibodies) in both humans and mice.

  4. The significant association of rs1552896 with an HIV-resistant phenotype, together with the expression profile of FREM1 in tissues relevant to HIV infection, suggests that FREM1 is a potentially novel candidate gene for resistance to HIV infection.

  5. The location of the IBD region 16 kb from FREM1 suggests the phenotype in Manitoba oculotrichoanal syndrome patients is attributable to a variant outside of FREM1, potentially in a regulatory element.

  6. FREM1 encodes a basement membrane protein of FRAS1-related extracellular matrix protein 1 which is required for epidermal adhesion during embryonic development

  7. a role for TILRR in selective amplification of NF-kappaB (show NFKB1 Antibodies) responses through IL-1RI and suggest that the specificity is determined by changes in receptor conformation and adapter protein (show TOLLIP Antibodies) recruitment.

  8. These data suggest that copy number variations and mutations involving FREM1 can be identified in a significant percentage of people with MC with or without midface hypoplasia.

  9. Manitoba-oculo-tricho-anal (MOTA) syndrome is caused by mutations in FREM1. FREM1 deficiency ties the molecular cause of MOTA syndrome closely to the pathogenesis of Fraser syndrome.

  10. TILRR, an isoform encoded by an alternatively spliced FREM1 mRNA, is an IL-1RI co-receptor that associates with the signaling receptor complex to enhance recruitment of MyD88 (show MYD88 Antibodies) and control Ras-dependent amplification of NF-kappaB (show NFKB1 Antibodies) and inflammatory responses.

Mouse (Murine) FRAS1 Related Extracellular Matrix 1 (FREM1) interaction partners

  1. loss of FREM1 function promotes epidermal blistering in Fraser syndrome as a consequence of reduced PDGFC (show PDGFC Antibodies) activity, in addition to its stabilising role in the basement membrane

  2. FREM1-deficient mice faithfully recapitulate many of the phenotypes seen in individuals with FREM1 deficiency and that variations in GATA4 (show GATA4 Antibodies) and SLIT3 (show SLIT3 Antibodies) expression modulate some FREM1-related phenotypes in mice.

  3. We conclude that FREM1 plays a critical role in the development of the diaphragm and that FREM1 deficiency can cause CDH (show CHDH Antibodies) in both humans and mice.

  4. the loss of QBRICK significantly diminished The expression of nephronectin (show NPNT Antibodies), an integrin alpha8beta1 ligand necessary for renal development.

  5. Frem1 mutant mice is the first bona fide mouse model of human metopic craniosynostosis and a new model for midfacial hypoplasia.

  6. TILRR, an isoform encoded by an alternatively spliced FREM1 mRNA, is an IL-1RI co-receptor that associates with the signaling receptor complex to enhance recruitment of MyD88 (show MYD88 Antibodies) and control Ras-dependent amplification of NF-kappaB (show NFKB1 Antibodies) and inflammatory responses.

  7. Frem1 appears to act as a dermal mediator of basement membrane adhesion and is required for epidermal adhesion during embryonic development

  8. QBRICK is an adhesive ligand of basement membrane distinctively recognized by cells in the embryonic skin and hair follicles through different types of integrins directed to the Arg-Gly-Asp (show C3 Antibodies) motif.

  9. QBRICK/Frem1, Fras1 (show FRAS1 Antibodies), and Frem2 (show FREM2 Antibodies) interactions at the basement membrane have roles in preventing Fraser syndrome-like defects

  10. Taken together, our findings indicate that besides a cooperative function with Fras1 (show FRAS1 Antibodies) in embryonic basement membranes, Frem1 can also act independently in processes related to epidermal differentiation.

FRAS1 Related Extracellular Matrix 1 (FREM1) Antigen Profile

Protein Summary

This gene encodes a basement membrane protein that may play a role in craniofacial and renal development. Mutations in this gene have been associated with bifid nose with or without anorectal and renal anomalies. Alternatively spliced transcript variants encoding different isoforms have been described. PubMed ID 19940113 describes one such variant that initiates transcription within a distinct, internal exon\; the resulting shorter isoform (named Toll-like/interleukin-1 receptor regulator, TILRR) is suggested to be a co-receptor of the interleukin 1 receptor family and may regulate receptor function and Toll-like receptor/interleukin 1 receptor signal transduction, contributing to the control of inflammatory response activation.

Gene names and symbols associated with FREM1

  • FRAS1 related extracellular matrix 1 (FREM1) antibody
  • Fras1 related extracellular matrix 1 (Frem1) antibody
  • Fras1 related extracellular matrix protein 1 (Frem1) antibody
  • BC037594 antibody
  • BNAR antibody
  • C9orf143 antibody
  • C9orf145 antibody
  • C9orf154 antibody
  • D430009N09 antibody
  • D630008K06 antibody
  • eye antibody
  • eyes2 antibody
  • heb antibody
  • MOTA antibody
  • qbrick antibody
  • RGD1306981 antibody
  • TILRR antibody
  • TRIGNO2 antibody

Protein level used designations for FREM1

FRAS1-related extracellular matrix protein 1 , extracellular matrix protein QBRICK

GENE ID SPECIES
158326 Homo sapiens
481547 Canis lupus familiaris
298185 Rattus norvegicus
329872 Mus musculus
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