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FSHD Region Gene 1 Proteins (FRG1)

FRG1 maps to a location 100 kb centromeric of the repeat units on chromosome 4q35 which are deleted in facioscapulohumeral muscular dystrophy (FSHD). Additionally we are shipping FSHD Region Gene 1 Antibodies (70) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat FRG1 FRG1 361156  
FRG1 2483 Q14331
FRG1 14300 P97376
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Top FSHD Region Gene 1 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Takifugu rubripes His tag   1 mg Log in to see 56 to 66 Days
$2,656.50
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

FRG1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for FSHD Region Gene 1 (FRG1) Interaction Partners

Human FSHD Region Gene 1 (FRG1) interaction partners

  1. Our results demonstrate that FRG1 is a direct DUX4 transcriptional target uncovering a novel regulatory circuit contributing to Facioscapulohumeral muscular dystrophy.

  2. FRG1 mice overexpressing FHL1 (show FHL1 Proteins) showed an improvement in the dystrophic phenotype

  3. This study suggests a novel role of FRG1 as epigenetic regulator of muscle differentiation and indicates that Suv4-20h1 (show SUV420H1 Proteins) has a gene-specific function in myogenesis.

  4. depressed myoblast proliferation may contribute to the pathology of mice overexpressing FRG1 and may play a part in facioscapulohumeral muscular dystrophy

  5. These data provide the first biochemical activities (actin binding and RNA binding) for human FRG1 and the characterization of the endogenous human FRG1, together indicating that FRG1 is involved in multiple aspects of RNA biogenesis.

  6. in muscle FRG1 is a developmentally regulated sarcomeric protein suggesting FRG1 may perform a muscle-specific (show EIF3K Proteins) function

  7. FRG1 transgenic mice develop a muscular dystrophy with features characteristic of the human disease; by contrast, FRG2 and ANT1 (show SLC25A4 Proteins) transgenic mice seem normal

  8. differently from normal myoblasts, the 4qA/B marker interacted directly with the promoters of the FRG1 and ANT1 (show SLC25A4 Proteins) genes in Facio-Scapulo-Humeral Dystrophy cells

  9. Data show that frg1 is expressed in and essential for the development of the tadpole musculature, and suggest that maintenance of normal FRG1 levels is critical for proper muscle development in frogs and humans.

  10. study compared chromatin structure & tridimensional interaction of the D4Z4 array and FRG1 gene promoter, and FRG1 expression, in control and FSHD cells

Mouse (Murine) FSHD Region Gene 1 (FRG1) interaction partners

  1. Mouse Frg1 genomic area lacks DUX4 binding sites and DUX4 is unable to activate the endogenous mouse Frg1 gene providing a possible explanation for the lack of muscle phenotype in DUX4 transgenic mice.

  2. This study suggests a novel role of FRG1 as epigenetic regulator of muscle differentiation and indicates that Suv4-20h1 (show SUV420H1 Proteins) has a gene-specific function in myogenesis.

  3. On the basis of these results, it was proposed that aberrant fTnT represents a biological marker of muscle phenotype severity and disease progression.

  4. our results suggest that a component of FSHD pathogenesis may arise by over-expression of FRG1, reducing Rbfox1 (show A2BP1 Proteins) levels and leading to aberrant expression of an altered Calpain 3 (show CAPN3 Proteins) protein through dysregulated splicing

FSHD Region Gene 1 (FRG1) Protein Profile

Protein Summary

This gene maps to a location 100 kb centromeric of the repeat units on chromosome 4q35 which are deleted in facioscapulohumeral muscular dystrophy (FSHD). It is evolutionarily conserved and has related sequences on multiple human chromosomes but DNA sequence analysis did not reveal any homology to known genes. In vivo studies demonstrate the encoded protein is localized to the nucleolus.

Gene names and symbols associated with FSHD Region Gene 1 Proteins (FRG1)

  • FSHD region gene 1-like (Frg1l)
  • FSHD region gene 1 (FRG1)
  • FSHD region gene 1 (frg1)
  • FSHD region gene 1 (LOC100345738)
  • FRG1 protein (frg1)
  • FSHD region gene 1 (Frg1)
  • frg1 protein
  • FRG1A protein
  • FSG1 protein
  • MGC84293 protein
  • MGC89908 protein

Protein level used designations for FSHD Region Gene 1 Proteins (FRG1)

FSHD region gene 1-like , FSHD region gene 1 , protein FRG1 , FSHD region gene 1 protein , facioscapulohumeral muscular dystrophy region gene-1

GENE ID SPECIES
361156 Rattus norvegicus
422726 Gallus gallus
444679 Xenopus laevis
448726 Xenopus (Silurana) tropicalis
482899 Canis lupus familiaris
698743 Macaca mulatta
738279 Pan troglodytes
100345738 Oryctolagus cuniculus
445937 Takifugu rubripes
2483 Homo sapiens
14300 Mus musculus
689484 Rattus norvegicus
512533 Bos taurus
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