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FUNDC1 encodes a protein with a FUN14 superfamily domain. Additionally we are shipping FUNDC1 Antibodies (69) and FUNDC1 Kits (3) and many more products for this protein.
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MARCH5 (show MARCH5 Proteins) directly interacts with FUNDC1 to mediate its ubiquitylation at lysine 119 for subsequent degradation.
FUNDC1 integrates mitochondrial fission and mitophagy at the interface of the endoplasmic reticulum-mitochondrial contact site by working in concert with DRP1 (show CRMP1 Proteins) and calnexin (show CANX Proteins) under hypoxic conditions in mammalian cells.
structural and biochemical results reveal a working model for the specific recognition of FUNDC1 by LC3B (show MAP1LC3B Proteins) and imply that the reversible phosphorylation modification of mitophagy receptors may be a switch for selective mitophagy.
FUNDC1 regulates both mitochondrial fission or fusion and mitophagy.
The BCL2L1 (show BCL2L1 Proteins)-PGAM5 (show PGAM5 Proteins)-FUNDC1 axis is critical for receptor-mediated mitophagy.
FUNDC1 regulates ULK1 (show ULK1 Proteins) recruitment to damaged mitochondria, where FUNDC1 phosphorylation by ULK1 (show ULK1 Proteins) is crucial for mitophagy.
Data show that Knockdown of endogenous FUNDC1 significantly prevented hypoxia-induced mitophagy, which could be reversed by the expression of wild-type FUNDC1.
MicroRNA-137 has a role in inhibiting mitophagy via regulation of two mitophagy receptors FUNDC1 and NIX (show BNIP3L Proteins)
This gene encodes a protein with a FUN14 superfamily domain. The function of the encoded protein is not known.
FUN14 domain-containing protein 1
, FUN14 domain-containing protein 1A