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anti-FXYD Domain Containing Ion Transport Regulator 1 (FXYD1) Antibodies

FXYD1 encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. Additionally we are shipping FXYD1 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FXYD1 5348 O00168
FXYD1 56188 Q9Z239
FXYD1 58971  
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Top anti-FXYD1 Antibodies at antibodies-online.com

Showing 10 out of 87 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Mouse Rabbit Un-conjugated WB PLM Antibody (E1) (ABIN1882173) western blot analysis in mouse heart,skeletal muscle and rat heart,skeletal muscle tissue lysates (35 µg/lane). This demonstrates the PLM antibody detected the PLM protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Mouse Rabbit Un-conjugated DB, WB Dot blot analysis of anti-Phospho-mPLM-pS88.repeat Phospho-specific Pab (ABIN389683) on nitrocellulose membrane.  50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 µg/mL. The anti-Mouse Phospho-PLM-pS88 Pab (ABIN389683) is used for detection in mouse heart tissue lysate. Mouse Phospho-PLM-pS88 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Mouse Mouse Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Mouse Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- FXYZ1 Picoband antibody, IHC(P) IHC(P): Rat Cardiac Muscle Tissue Anti- FXYZ1 Picoband antibody, IHC(P) IHC(P): Human Prostatic Cancer Tissue 100 μg Log in to see 4 to 6 Days
$240.00
Details
Mouse Mouse Un-conjugated WB Western blot analysis of anti-PLM Mab (ABIN387765) in 293 cells transfected with a plasmid encoding PLM. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Mouse Rabbit Alkaline Phosphatase (AP) ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Alexa Fluor 647 IF (p)   100 μL Log in to see 14 to 21 Days
$379.50
Details

FXYD1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-FXYD1 Antibodies

  1. Chicken Polyclonal FXYD1 Primary Antibody for WB - ABIN2782662 : Lifshitz, Petrovich, Haviv, Goldshleger, Tal, Garty, Karlish: Purification of the human alpha2 Isoform of Na,K-ATPase expressed in Pichia pastoris. Stabilization by lipids and FXYD1. in Biochemistry 2007 (PubMed)

  2. Mouse (Murine) Polyclonal FXYD1 Primary Antibody for WB - ABIN1882173 : Nakajima-Takenaka, Zhang, Obata, Tohne, Matsuyoshi, Nagai, Nishiyama, Takaki: Left ventricular function of isoproterenol-induced hypertrophied rat hearts perfused with blood: mechanical work and energetics. in American journal of physiology. Heart and circulatory physiology 2009 (PubMed)

More Antibodies against FXYD1 Interaction Partners

Human FXYD Domain Containing Ion Transport Regulator 1 (FXYD1) interaction partners

  1. Study demonstrated that the expression of FXYD1, FXYD3 (show FXYD3 Antibodies) and FXYD5 (show FXYD5 Antibodies) is elevated in the lungs of Acute respiratory distress syndrome patients

  2. a period of high-intensity training with reduced training volume increases expression and phosphorylation levels of FXYD1, which may affect Na(+)/K(+) pump activity and muscle K(+) homeostasis during intense exercise.

  3. Stopped-flow experiments using the dye RH421 show that FXYD1 slows the conformational transition E2(2K)ATP --> E1(3Na)ATP but does not affect 3NaE1P --> E2P3Na.

  4. the evolutionary conservation of G-quadruplex forming sequences with the confirmation of G-quadruplex formation in vitro by two FXYD1 homologues

  5. Phospholemman is the target of a variety of post-translational modifications and these can dynamically alter the activity of the Na pump. [Review]

  6. PLM regulates important ion transporters in the heart and offers a tempting target for development of drugs to treat heart failure.

  7. Intracellular trafficking of FXYD1 (phospholemman) and FXYD7 (show FXYD7 Antibodies) proteins in Xenopus oocytes and mammalian cells.

  8. the severity of the spinal cord lesion is an important factor controlling the expression of Na(+)-K(+)-ATPase (show ATP1A1 Antibodies) and its regulatory protein PLM

  9. in left ventricular myocardium from patients with heart failure, PLM Ser (show SIGLEC1 Antibodies)-68 phosphorylation was approximately 50% lower than in nonfailing controls

  10. Exercise induces FXYD1 phosphorylation at multiple sites in human muscle; in mice, contraction-induced changes in FXYD1 phosphorylation are fiber-type specific and dependent on protein kinase (show CDK7 Antibodies) Calpha (show PRKACA Antibodies) activity.

Cow (Bovine) FXYD Domain Containing Ion Transport Regulator 1 (FXYD1) interaction partners

  1. the evolutionary conservation of G-quadruplex forming sequences with the confirmation of G-quadruplex formation in vitro by two FXYD1 homologues

Pig (Porcine) FXYD Domain Containing Ion Transport Regulator 1 (FXYD1) interaction partners

  1. S68 phospholemman phosphorylation may be involved in cAMP-dependent regulation of smooth muscle force.

  2. Phospholemman does not participate in forskolin-induced swine carotid artery relaxation.

Mouse (Murine) FXYD Domain Containing Ion Transport Regulator 1 (FXYD1) interaction partners

  1. Both the extracellular PFXYD motif and the transmembrane domain of PLM but not the cytoplasmic tail were necessary for regulation of peak L-type Ca(2 (show CA2 Antibodies)+) current amplitude.

  2. Decreased phosphorylation of PLM reduces Na/K pump activity and exacerbates Na overload, contractile dysfunction, and adverse remodelling following aortic constriction in mice.

  3. Nitric oxide activates Na/K-ATPase (show ATP1A1 Antibodies) via phospholemman phosphorylation.

  4. The results of this study indicated that reducing FXYD1 levels improves a specific cognitive impairment in MECP2 (show MECP2 Antibodies)-deficient mice.

  5. Alterations in PLM expression and phosphorylation are important adaptations post-myocardial infarction.

  6. Exercise induces FXYD1 phosphorylation at multiple sites in human muscle; in mice, contraction-induced changes in FXYD1 phosphorylation are fiber-type specific and dependent on protein kinase (show CDK7 Antibodies) Calpha (show PRKACA Antibodies) activity.

  7. The results of this study showed the involvement of epigenetic mechanisms in the manifestation of brain region-specific differences in Fxyd1 expression.

  8. Under catecholamine stress when [Na+]i is high, phospholemman minimizes [Na+]i overload by relieving its inhibition of Na+-K+-ATPase (show ATP1A1 Antibodies) and preserves inotropy by simultaneously inhibiting Na+/Ca2+ exchanger (show SLC8A1 Antibodies).

  9. Under stressful conditions in which [Na(+)](i) was high, beta-adrenergic agonist-mediated phosphorylation of phospholemman resulted in time-dependent reduction in inotropy due to relief of inhibition of Na(+)-K(+)-ATPase (show ATP1A1 Antibodies).

  10. a primary effect of phospholemman is to modulate the Na-K-ATPase (show ATP1A1 Antibodies) and that its reduced activity initiates compensatory responses in heart hypertrophy

FXYD1 Antigen Profile

Protein Summary

This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. Transcript variants with different 5' UTR sequences have been described in the literature.

Gene names and symbols associated with FXYD1

  • FXYD domain containing ion transport regulator 1 (FXYD1) antibody
  • FXYD domain-containing ion transport regulator 1 (Fxyd1) antibody
  • 0610012C17Rik antibody
  • 1110006M24Rik antibody
  • Plm antibody
  • Pml antibody

Protein level used designations for FXYD1

FXYD domain containing ion transport regulator 1 , phospholemman , FXYD domain containing ion transport regulator 1 (phospholemman) , FXYD domain-containing ion transport regulator 1

GENE ID SPECIES
747770 Pan troglodytes
5348 Homo sapiens
476487 Canis lupus familiaris
616139 Bos taurus
100127481 Sus scrofa
56188 Mus musculus
58971 Rattus norvegicus
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