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FXYD Domain Containing Ion Transport Regulator 5 Proteins (FXYD5)

FXYD5 encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. Additionally we are shipping FXYD5 Antibodies (57) and FXYD5 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FXYD5 53827 Q96DB9
FXYD5 18301 P97808
FXYD5 60338 P59647
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Top FXYD5 Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,253.17
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$413.21
Details

FXYD5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
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Mouse (Murine) ,
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Rat (Rattus)

Top referenced FXYD5 Proteins

  1. Human FXYD5 Protein expressed in Escherichia coli (E. coli) - ABIN1098542 : Sato, Ino, Miura, Abe, Sakai, Ito, Hirohashi: Dysadherin: expression and clinical significance in thyroid carcinoma. in The Journal of clinical endocrinology and metabolism 2003 (PubMed)
    Show all 2 references for ABIN1098542

More Proteins for FXYD Domain Containing Ion Transport Regulator 5 (FXYD5) Interaction Partners

Human FXYD Domain Containing Ion Transport Regulator 5 (FXYD5) interaction partners

  1. Study demonstrated that the expression of FXYD1 (show FXYD1 Proteins), FXYD3 (show FXYD3 Proteins) and FXYD5 is elevated in the lungs of Acute respiratory distress syndrome patients

  2. Dysadherin-silenced side population cells exhibited reduced expression of Bcl-2 (show BCL2 Proteins) and Bax (show BAX Proteins) compared with that prior to silencing.

  3. we are focusing on the role of dysadherin in E-cadherin (show CDH1 Proteins) downregulation, the various expression patterns of the molecule in head and neck cancer

  4. Findings suggest that dysadherin might contribute to breast cancer progression through AKT (show AKT1 Proteins) activation.

  5. These results suggest a role of let-7a down-regulation in the development of thyroid neoplasias of the follicular histotype, likely regulating dysadherin protein expression levels.

  6. Data show that osteoblasts are the major cell type of the bone marrow that affect RCC (show XRCC1 Proteins) cells by secreting factors that increase the expression of dysadherin and CCL2 (show CCL2 Proteins) in the tumor cells leading to enhanced cell migration.

  7. This is the first report on expression of dysadherin in the male gonad and in spermatozoa.

  8. Overexpression of Snail (show SNAI1 Proteins), Slug (show SNAI2 Proteins), and dysadherin and activation of Wnt (show WNT2 Proteins) and PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling was associated with inactivated E-cadherin (show CDH1 Proteins) in the spindle cells of monophasic fibrous synovial sarcomas.

  9. Combined dysadherin-positive expression and E-cadherin (show CDH1 Proteins)-negative expression may be valuable information for predicting aggressive tumor behavior of differentiated-type gastric carcinoma with submucosal invasion

  10. transfection of dysadherin cDNA into the liver cancer cell line PLC/PRF/5 enhanced the properties of cencer stem cells, including anti-apoptosis, their sphere-forming ability, side population phenotype, and tumor initiation ability in vivo

Mouse (Murine) FXYD Domain Containing Ion Transport Regulator 5 (FXYD5) interaction partners

  1. FXYD5 affects cell polarization through its interaction with Na(+)-K(+)-ATPase (show ATP1A1 Proteins).

  2. Expressing FXYD5 in mouse kidney collecting duct cell line M1 led to a large decrease in amiloride-insensitive transepithelial electrical resistance as well as increased permeability to 4-kDa dextran.

  3. The role of FXYD5 in Na,K-ATPase (show ATP1A1 Proteins) activity, its cellular and tissue distribution, and its biochemical properties are reported.

  4. data suggest that different FXYD proteins interact similarly with the Na(+)-K(+)-ATPase (show ATP1A1 Proteins) and their transmembrane domains

  5. FXYD5 is significantly increased in the lungs and nasal epithelium of cystic fibrosis (show S100A8 Proteins) mice as assessed by RT-PCR.

FXYD5 Protein Profile

Protein Summary

This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with FXYD5

  • FXYD domain containing ion transport regulator 5 (FXYD5)
  • FXYD domain-containing ion transport regulator 5 (Fxyd5)
  • DYSAD protein
  • EF-8 protein
  • FXYD5 protein
  • IWU1 protein
  • KCT1 protein
  • Oit2 protein
  • PRO6241 protein
  • RIC protein

Protein level used designations for FXYD5

FXYD domain-containing ion transport regulator 5 , FXYD domain containing ion transport regulator 5 , dysadherin , keratinocytes associated transmembrane protein 1 , ion channel homolog RIC , oncoprotein induced transcript 2 , oncoprotein-induced protein 2

GENE ID SPECIES
505584 Bos taurus
744650 Pan troglodytes
53827 Homo sapiens
18301 Mus musculus
60338 Rattus norvegicus
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