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This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. Additionally we are shipping FXYD7 Antibodies (52) and FXYD7 Proteins (3) and many more products for this protein.
Intracellular trafficking of FXYD1 (phospholemman (show FXYD1 ELISA Kits)) and FXYD7 proteins in Xenopus oocytes and mammalian cells.
Expressed in Xenopus oocytes, mouse FXYD7 can interact with Na,K-ATPase alpha 1-beta 1, alpha 2-beta 1 and alpha 3-beta 1 but not with alpha-beta 2 isozymes whereas, in brain, it is only associated with alpha 1-beta isozymes.
FXYD7 is a new member of proteins with a regulated ER export and has a particular regulatory function in brain
the the TM domain of FXYD7 has a role in mediating the complex interactions of FXYD7 with Na,K-ATPase (show ATP1A1 ELISA Kits)
This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not been characterized as a protein.
FXYD domain-containing ion transport regulator 7