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May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Additionally we are shipping FGD5 Antibodies (19) and many more products for this protein.
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FGD5 regulates endothelial adhesion, survival, and angiogenesis by modulating phosphatidylinositol 3-kinase signaling.
FGD5 inhibits neovascularization, indicated by in (show ARHGEF11 Proteins)vitro tube-formation, aortic-ring, and coated-bead assays and by in vivo coated-bead plug assays and studies in the murine retina model.
Suggest that FGD5 regulates proangiogenic action of VEGF in vascular endothelial cells, including network formation, permeability, directional movement, and proliferation.
Fgd5 identifies hematopoietic stem cells in the murine bone marrow.
A new endothelial specific gene named FYVE, RhoGEF, and PH domain-containing 5 (FGD5) plays a crucial role in vascular pruning in a murine model.
May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity).
FYVE, RhoGEF and PH domain-containing protein 5
, zinc finger FYVE domain-containing protein 23