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Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis (By similarity).. Additionally we are shipping and many more products for this protein.
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Dog (Canine) Polyclonal FAM176A Primary Antibody for WB - ABIN2773956
Wang, Yu, Lu, He, Guo, Zhang, Song, Ma, Shi, Chen: TMEM166, a novel transmembrane protein, regulates cell autophagy and apoptosis. in Apoptosis : an international journal on programmed cell death 2007
EVA1A interacts with the WD repeats of ATG16L1 (show ATG16L1 Antibodies) through its C-terminal and promotes ATG12 (show ATG12 Antibodies)-ATG5 (show ATG5 Antibodies)/ATG16L1 (show ATG16L1 Antibodies) complex recruitment to the autophagic membrane and enhances the formation of the autophagosome.
Low EVA1A expression is associated with glioblastoma.
The adenovirus-mediated increase of FAM176A inhibited the growth of the tumor cells.
TMEM166 expression was widely down-regulated in the cancer tissues.
Low TMEM166 mRNA and protein expression is associated with esophageal squamous cell carcinoma.
TMEM166 is a novel regulator involved in both autophagy and apoptosis.
EVA1A deletion results in defective self-renewal and differentiation of NSCs. EVA1A modulates autophagy through the PIK3CA (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies)-mTOR (show FRAP1 Antibodies) pathway.
Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis (By similarity).
family with sequence similarity 176, member A
, protein FAM176A
, transmembrane protein 166
, protein eva-1 homolog A