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Family with Sequence Similarity 20, Member C (FAM20C) ELISA Kits

FAM20C encodes a member of the family with sequence similarity 20 (FAM20) family of secreted proteins. Additionally we are shipping FAM20C Antibodies (30) and FAM20C Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human FAM20C FAM20C 56975 Q8IXL6
Anti-Mouse FAM20C FAM20C 80752 Q5MJS3
Anti-Rat FAM20C FAM20C 304334  
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More ELISA Kits for FAM20C Interaction Partners

Human Family with Sequence Similarity 20, Member C (FAM20C) interaction partners

  1. Fam20A (show FAM20A ELISA Kits) potentiates Fam20C kinase activity and promotes the phosphorylation of enamel matrix proteins in vitro.

  2. The Fam20C-and VLK-family of kinases mediate the phosphorylation of proteins in the secretory pathway and extracellular space.Mutation in several secretory pathway kinases cause human disease

  3. by treating Fam20C expressing HEK293T cells with myriocin, a potent inhibitor of the sphingosine biosynthetic pathway, the activity of Fam20C released into the conditioned medium is substantially decreased corroborating the concept that sphingosine

  4. Using CRISPR/Cas9 genome editing, mass spectrometry, and biochemistry, study identifies more than 100 secreted phosphoproteins as genuine Fam20C substrates; further, study shows that Fam20C exhibits broader substrate specificity than previously appreciated.

  5. phenotype in two families with non-lethal Raine syndrome with FAM20C mutations

  6. Findings suggest that certain homozygous FAM20C mutations can cause FGF23 (show FGF23 ELISA Kits)-related hypophosphatemic osteomalacia and indicate the multiple roles of FAM20C in bone.

  7. Results suggest that FAM20C suppresses FGF23 (show FGF23 ELISA Kits) production by enhancing DMP1 (show DMP1 ELISA Kits) expression, and inactivating mutations in FAM20C cause FGF23 (show FGF23 ELISA Kits)-related hypophosphatemia by decreasing transcription of DMP1 (show DMP1 ELISA Kits).

  8. We report on a child who is homozygous for a 487-kb deletion in 7p22.3 that contains FAM20C

  9. Fam20C phosphorylates FGF23 (show FGF23 ELISA Kits), which promotes FGF23 (show FGF23 ELISA Kits) proteolysis by furin (show FURIN ELISA Kits) by blocking O-glycosylation by polypeptide N-acetylgalactosaminyltransferase 3 (show GALNT3 ELISA Kits).

  10. mutations in FAM20C provide a putative new mechanism in human subjects leading to dysregulated FGF23 (show FGF23 ELISA Kits) levels, hypophosphatemia, hyperphosphaturia, dental anomalies, intracerebral calcifications and osteosclerosis of the long bones

Mouse (Murine) Family with Sequence Similarity 20, Member C (FAM20C) interaction partners

  1. Fam20A (show FAM20A ELISA Kits) potentiates Fam20C kinase activity and promotes the phosphorylation of enamel matrix proteins in vitro.

  2. Loss of Fam20C function leads to periodontal disease in mice

  3. Successful generation of Fam20C-GFP transgenic mice will provide a unique model for studying Fam20C gene expression and the biological function of this gene during odontogenesis and osteogenesis

  4. we have successfully generated the immortalized mouse floxed Fam20c dental papilla mesenchymal and osteoblast cell lines.

  5. These results indicated that the downregulation of Dmp1 (show DMP1 ELISA Kits) may not directly associate with, or significantly contribute to the bone and dentin defects in the Fam20C-cKO mice.

  6. that FAM20C is not a constituent of the enamel extracellular matrix and functions intracellularly within ameloblasts.

  7. FAM20C is a molecule essential to amelogenesis, its inactivation in the dental epithelium does not significantly affect dentinogenesis.

  8. FAM20C is essential to the differentiation and mineralization of dental tissues through the regulation of molecules critical to the differentiation of tooth-formative cells.

  9. Our findings indicate that FAM20C is essential to the differentiation of osteoblasts/osteocytes and is involved in the regulation of phosphate homeostasis via the mediation of FGF23 (show FGF23 ELISA Kits)

  10. Fam20c null mice develop hypophosphatemic rickets and defective enamel and dentin

FAM20C Antigen Profile

Antigen Summary

This gene encodes a member of the family with sequence similarity 20 (FAM20) family of secreted proteins. A similar gene in mice encodes a protein that plays a role in dentin mineralization, and mutations in the human gene are associated with the autosomal recessive disorder Raine syndrome.

Gene names and symbols associated with FAM20C

  • family with sequence similarity 20, member C (LOC100231802) antibody
  • family with sequence similarity 20, member C (LOC100342945) antibody
  • family with sequence similarity 20, member C (FAM20C) antibody
  • family with sequence similarity 20, member C (Fam20c) antibody
  • family with sequence similarity 20, member C (fam20c) antibody
  • C76981 antibody
  • DMP-4 antibody
  • DMP4 antibody
  • GEF-CK antibody
  • mKIAA4081 antibody
  • RGD1311980 antibody
  • RNS antibody
  • si:ch73-266a4.1 antibody

Protein level used designations for FAM20C

family with sequence similarity 20, member C , dentin matrix protein 4 , extracellular serine/threonine protein kinase FAM20C , golgi-enriched fraction casein kinase , fam20c2

GENE ID SPECIES
100231802 Taeniopygia guttata
100342945 Oryctolagus cuniculus
416445 Gallus gallus
56975 Homo sapiens
491596 Canis lupus familiaris
80752 Mus musculus
304334 Rattus norvegicus
560397 Danio rerio
534672 Bos taurus
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