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Family with Sequence Similarity 20, Member C Proteins (FAM20C)

FAM20C encodes a member of the family with sequence similarity 20 (FAM20) family of secreted proteins. Additionally we are shipping FAM20C Antibodies (26) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FAM20C 56975 Q8IXL6
FAM20C 80752 Q5MJS3
Rat FAM20C FAM20C 304334  
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Top FAM20C Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Baculovirus infected Insect Cells Human His tag   100 μg Log in to see 16 Days
$437.80
Details

FAM20C Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)

More Proteins for Family with Sequence Similarity 20, Member C (FAM20C) Interaction Partners

Human Family with Sequence Similarity 20, Member C (FAM20C) interaction partners

  1. Fam20A (show FAM20A Proteins) potentiates Fam20C kinase activity and promotes the phosphorylation of enamel matrix proteins in vitro.

  2. The Fam20C-and VLK (show PKDCC Proteins)-family of kinases mediate the phosphorylation of proteins in the secretory pathway and extracellular space.Mutation in several secretory pathway kinases cause human disease

  3. by treating Fam20C expressing HEK293T cells with myriocin, a potent inhibitor of the sphingosine biosynthetic pathway, the activity of Fam20C released into the conditioned medium is substantially decreased corroborating the concept that sphingosine

  4. Using CRISPR/Cas9 genome editing, mass spectrometry, and biochemistry, study identifies more than 100 secreted phosphoproteins as genuine Fam20C substrates; further, study shows that Fam20C exhibits broader substrate specificity than previously appreciated.

  5. phenotype in two families with non-lethal Raine syndrome with FAM20C mutations

  6. Findings suggest that certain homozygous FAM20C mutations can cause FGF23 (show FGF23 Proteins)-related hypophosphatemic osteomalacia and indicate the multiple roles of FAM20C in bone.

  7. Results suggest that FAM20C suppresses FGF23 (show FGF23 Proteins) production by enhancing DMP1 (show DMP1 Proteins) expression, and inactivating mutations in FAM20C cause FGF23 (show FGF23 Proteins)-related hypophosphatemia by decreasing transcription of DMP1 (show DMP1 Proteins).

  8. We report on a child who is homozygous for a 487-kb deletion in 7p22.3 that contains FAM20C

  9. Fam20C phosphorylates FGF23 (show FGF23 Proteins), which promotes FGF23 (show FGF23 Proteins) proteolysis by furin (show FURIN Proteins) by blocking O-glycosylation by polypeptide N-acetylgalactosaminyltransferase 3 (show GALNT3 Proteins).

  10. mutations in FAM20C provide a putative new mechanism in human subjects leading to dysregulated FGF23 (show FGF23 Proteins) levels, hypophosphatemia, hyperphosphaturia, dental anomalies, intracerebral calcifications and osteosclerosis of the long bones

Mouse (Murine) Family with Sequence Similarity 20, Member C (FAM20C) interaction partners

  1. Fam20A (show FAM20A Proteins) potentiates Fam20C kinase activity and promotes the phosphorylation of enamel matrix proteins in vitro.

  2. Loss of Fam20C function leads to periodontal disease in mice

  3. Successful generation of Fam20C-GFP transgenic mice will provide a unique model for studying Fam20C gene expression and the biological function of this gene during odontogenesis and osteogenesis

  4. we have successfully generated the immortalized mouse floxed Fam20c dental papilla mesenchymal and osteoblast cell lines.

  5. These results indicated that the downregulation of Dmp1 (show DMP1 Proteins) may not directly associate with, or significantly contribute to the bone and dentin defects in the Fam20C-cKO mice.

  6. that FAM20C is not a constituent of the enamel extracellular matrix and functions intracellularly within ameloblasts.

  7. FAM20C is a molecule essential to amelogenesis, its inactivation in the dental epithelium does not significantly affect dentinogenesis.

  8. FAM20C is essential to the differentiation and mineralization of dental tissues through the regulation of molecules critical to the differentiation of tooth-formative cells.

  9. Our findings indicate that FAM20C is essential to the differentiation of osteoblasts/osteocytes and is involved in the regulation of phosphate homeostasis via the mediation of FGF23 (show FGF23 Proteins)

  10. Fam20c null mice develop hypophosphatemic rickets and defective enamel and dentin

FAM20C Protein Profile

Protein Summary

This gene encodes a member of the family with sequence similarity 20 (FAM20) family of secreted proteins. A similar gene in mice encodes a protein that plays a role in dentin mineralization, and mutations in the human gene are associated with the autosomal recessive disorder Raine syndrome.

Gene names and symbols associated with FAM20C

  • family with sequence similarity 20, member C (LOC100231802)
  • family with sequence similarity 20, member C (LOC100342945)
  • family with sequence similarity 20, member C (FAM20C)
  • family with sequence similarity 20, member C (Fam20c)
  • family with sequence similarity 20, member C (fam20c)
  • C76981 protein
  • DMP-4 protein
  • DMP4 protein
  • GEF-CK protein
  • mKIAA4081 protein
  • RGD1311980 protein
  • RNS protein
  • si:ch73-266a4.1 protein

Protein level used designations for FAM20C

family with sequence similarity 20, member C , dentin matrix protein 4 , extracellular serine/threonine protein kinase FAM20C , golgi-enriched fraction casein kinase , fam20c2

GENE ID SPECIES
100231802 Taeniopygia guttata
100342945 Oryctolagus cuniculus
416445 Gallus gallus
56975 Homo sapiens
491596 Canis lupus familiaris
80752 Mus musculus
304334 Rattus norvegicus
560397 Danio rerio
534672 Bos taurus
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