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anti-Family with Sequence Similarity 3, Member B (FAM3B) Antibodies

Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner. Additionally we are shipping Family with Sequence Similarity 3, Member B Kits (52) and Family with Sequence Similarity 3, Member B Proteins (12) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FAM3B 54097 P58499
FAM3B 52793 Q9D309
FAM3B 304050  
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Top anti-Family with Sequence Similarity 3, Member B Antibodies at antibodies-online.com

Showing 10 out of 64 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of FAM3B Antibody (N-term) (ABIN390878) in Hela cell line lysates (35 µg/lane). FAM3B (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human colon carcinoma reacted with FAM3B Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 14 Days
$369.79
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat pancreas tissue labeled Anti-FAM3B/PANDER Polyclonal Antibody, Unconjugated (ABIN672201) at 1:200, followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Mouse Rabbit Un-conjugated IHC, WB Western blot analysis of PC-3 cell lysate using FAM3B antibody. 100 μL Log in to see 9 Days
$302.50
Details
Human Mouse Un-conjugated IHC (p), IP, ELISA, WB 100 μg Log in to see 8 to 10 Days
$537.17
Details
Human Rabbit Alkaline Phosphatase (AP) ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Sheep Un-conjugated ELISA Immunohistochemical staining of formalin-fixed paraffin-embedded human pancreas using this product at a concentration of 2 µg/mL (original magnification, 20x (left) and 40x (right)). Detection DAB. Diffuse staining in the endocrine and exocrine areas of the pancreas. 0.1 mg Log in to see 5 to 6 Days
$303.60
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details

FAM3B Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Family with Sequence Similarity 3, Member B Antibodies

  1. Human Polyclonal FAM3B Primary Antibody for EIA, WB - ABIN452988 : Yang, Gao, Robert, Burkhardt, Gaweska, Wagner, Wu, Greene, Young, Wolf: Structure-function studies of PANDER, an islet specific cytokine inducing cell death of insulin-secreting beta cells. in Biochemistry 2005 (PubMed)

More Antibodies against Family with Sequence Similarity 3, Member B Interaction Partners

Human Family with Sequence Similarity 3, Member B (FAM3B) interaction partners

  1. in-vitro and in-vivo glucose is a potent stimulator of the PANDER promoter within the liver and this response may be facilitated by ChREBP (show MLXIPL Antibodies).

  2. beta-cell-secreted PANDER regulated the hepatic insulin (show INS Antibodies) and lipogenenic signaling and impact overall glycemia.

  3. our studies demonstrated that silencing FAM3B promoted p53 (show TP53 Antibodies) phosphorylation and induced p53 (show TP53 Antibodies) accumulation by decreasing Mdm2 (show MDM2 Antibodies) expression, which resulted in apoptotic cell death.

  4. These results suggest that FAM3B-258 promotes colon cancer cell invasion and metastasis through upregulation of Slug (show SNAI2 Antibodies).

  5. Helices B and C and the second disulfide bond of PANDER are essential for PANDER-induced beta-cell death.

  6. PANDER is secreted from 2 types of pancreatic cells, glucose stimulates its secretion in beta cell and primary islets but not in alpha-cells, it is likely cosecreted with insulin (show INS Antibodies), and structure and conformation is vital for PANDER secretion.

Mouse (Murine) Family with Sequence Similarity 3, Member B (FAM3B) interaction partners

  1. in-vitro and in-vivo glucose is a potent stimulator of the PANDER promoter within the liver and this response may be facilitated by ChREBP (show MLXIPL Antibodies).

  2. F3MB(PANDER) decreases mice hepatic triglyceride and is associated with decreased DGAT1 (show DGAT1 Antibodies) expression

  3. X-ray crystal structure of the mouse FAM3B protein.

  4. these results demonstrated that the JNK (show MAPK8 Antibodies)-mediated signaling mechanism of palmitic acid -induced beta-cell apoptosis involves up-regulated expression of PANDER and activation of caspase-3 (show CASP3 Antibodies).

  5. Data suggest a new link between the endocrine and immune systems and provide useful information for further investigating the physiological functions of PANDER and its involvement in inflammation-related pancreatic disorders.

  6. Palmitic acid induces the expression of PANDER and the apoptosis of beta-TC3 cells while glucagon-like peptide-1 (show GCG Antibodies) counteracts the above effects through an activation of Akt (show AKT1 Antibodies) signaling.

  7. PANDER promotes lipogenesis and compromises insulin (show INS Antibodies) signaling in the liver by increasing FOXO1 (show FOXO1 Antibodies) activity.

  8. Findings further indicate PANDER impacts glycemic levels and may represent a potential but complicated therapeutic target.

  9. A paracrine/endocrine effect of insulin (show INS Antibodies) on Pander release and a potential glucose-regulatory role for Pander.

  10. we provide evidence that identifies PANDER as a regulator of hepatic glucose metabolism, where it amplifies hepatic cAMP and cAMP-response element-binding protein signaling to induce gluconeogenic gene expression and glucose output.

Family with Sequence Similarity 3, Member B (FAM3B) Antigen Profile

Protein Summary

Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner. Present in insulin secretory granules and likely cosecreted with insulin.

Gene names and symbols associated with FAM3B

  • family with sequence similarity 3, member B (LOC100221253) antibody
  • family with sequence similarity 3, member B (FAM3B) antibody
  • family with sequence similarity 3, member B (Fam3b) antibody
  • 2-21 antibody
  • 9030624C24Rik antibody
  • C21orf11 antibody
  • C21orf76 antibody
  • D16Jhu19e antibody
  • ORF9 antibody
  • Pander antibody
  • RGD1311662 antibody

Protein level used designations for FAM3B

family with sequence similarity 3, member B , D21M16SJHU19e , cytokine-like protein 2-21 , pancreatic derived factor , pancreatic-derived factor , protein FAM3B

GENE ID SPECIES
100221253 Taeniopygia guttata
54097 Homo sapiens
52793 Mus musculus
514701 Bos taurus
478419 Canis lupus familiaris
418527 Gallus gallus
100517916 Sus scrofa
304050 Rattus norvegicus
101119956 Ovis aries
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