Family with Sequence Similarity 3, Member C Proteins (FAM3C)

FAM3C is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. Additionally we are shipping FAM3C Antibodies (53) and FAM3C Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FAM3C 10447 Q92520
FAM3C 27999 Q91VU0
FAM3C 312159 Q810F4
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Top FAM3C Proteins at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 15 to 19 Days
$407.00
Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Mammalian Cells Human His tag   50 μg Log in to see 4 Days
$385.00
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Human Human His tag   10 μg Log in to see 15 to 16 Days
$225.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Yeast Zebrafish His tag   1 mg Log in to see 60 to 71 Days
$2,476.83
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,495.17
Details

FAM3C Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , ,
, , , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Family with Sequence Similarity 3, Member C (FAM3C) Interaction Partners

Human Family with Sequence Similarity 3, Member C (FAM3C) interaction partners

  1. Covalent dimerization of ILEI is associated with breast cancer metastasis.

  2. Data suggest that ILEI does not form interleukin-like four helix-bundle structures; ILEI exists as monomers and as covalent dimers; ILEI dimer exhibits a trans-linked domain swap converting an intramolecular disulfide to an intermolecular disulfide; dimeric ILEI appears to be involved in neoplastic invasiveness.

  3. Results demonstrate that phenotype switching regulates ILEI expression, and that ILEI regulates partial phenotype switching in MITF (show MITF Proteins)-low melanoma cell lines.

  4. Ectopic overexpression of UBE4A, but not UBE3C (show UBE3C Proteins), in cells was downregulated in vitro migration and invasion in these cells. Cumulatively, our data reveals a novel post-translational regulatory mechanism of regulating ILEI1 expression, a protein required for metastatic progression in prostate cancer cells

  5. Study used immunohistochemical staining and biochemical fractionation to examine the regional distribution and subcellular localization of ILEI in mouse brains and in autopsy brains of patients with Alzheimer's disease; results suggest that a decline of ILEI expression may cause accumulation of Abeta (show APP Proteins) in the brain and the eventual development of Alzheimer's disease.

  6. FAM3C expression was dramatically increased in esophageal squamous cell carcinoma and might serve as a valuable prognostic indicator for esophageal squamous cell carcinoma patients after surgery

  7. Altered subcellular ILEI localization strongly correlates with high tumor cell-associated uPAR (show PLAUR Proteins) protein expression.

  8. Our findings indicate that cytoplasmic ILEI expression is a potential marker of EMT (show ITK Proteins) and tumour progression in colorectal cancer. ILEI is an independent predictive factor associated with poor prognosis in colorectal cancer.

  9. ILEI could induce, as well as maintain, CD24 (show CD24 Proteins)(low)CD44 (show CD44 Proteins)(high) subpopulation in A549 cells treated with TGF-beta (show TGFB1 Proteins), which might explain its capability to induce metastatic progression.

  10. At the FAM3C gene locus where rs7776725 was located, we identified several other SNPs (rs4727922, rs1803389, rs718766 and rs7793554) that were also associated with BMD (show BEST1 Proteins).

Mouse (Murine) Family with Sequence Similarity 3, Member C (FAM3C) interaction partners

  1. Data suggest that Ilei does not form interleukin-like four helix-bundle structures; Ilei exists as monomers and as covalent dimers; Ilei dimer exhibits a trans-linked domain swap converting an intramolecular disulfide to an intermolecular disulfide; dimeric Ilei appears to be involved in neoplastic invasiveness.

  2. overexpression of Fam3c caused reduction of Runx2 (show RUNX2 Proteins) expression at both mRNA and protein levels. Fam3c was localized in the cytoplasm and it was not secreted outside the cell during osteoblast differentiation and therefore, may function intracellularly. Furthermore, Fam3c and TGF-beta1 (show TGFB1 Proteins) were found to regulate each other reciprocally

  3. In obese diabetic mice, FAM3C expression was reduced in the liver, and hepatic FAM3C restoration improved insulin (show INS Proteins) resistance, hyperglycemia, and fatty liver. FAM3C overexpression increased the expression of heat shock factor 1 (HSF1), calmodulin (CaM), and phosphorylated Akt (show AKT1 Proteins) and reduced that of gluconeogenic and lipogenic genes in diabetic mouse livers with the suppression of gluconeogenesis and lipid deposition.

  4. Study used immunohistochemical staining and biochemical fractionation to examine the regional distribution and subcellular localization of ILEI in mouse brains and in autopsy brains of patients with Alzheimer's disease; results suggest that a decline of ILEI expression may cause accumulation of Abeta (show APP Proteins) in the brain and the eventual development of Alzheimer's disease.

  5. TGF-beta (show TGFB1 Proteins) modulates the expression of Dab2 (show DAB2 Proteins) and ILEI mRNA required for epithelial-mesenchymal transdifferentiation by inducing phosphorylation of hnRNP E1 (show PCBP1 Proteins), resulting in its release from a structural, 33-nucleotide BAT (show BAAT Proteins) element in the 3'UTR of Dab2 (show DAB2 Proteins) and ILEI.

  6. FAM3C orthologous protein, may be involved in cell differentiation and proliferation during inner ear embryogenesis

  7. ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors.

  8. ILEI requires cooperation with oncogenic Ras to govern hepatocellular EMT (show ITK Proteins) through mechanisms involving PDGF-R/beta (show PDGFRB Proteins)-catenin (show CTNNB1 Proteins) and PDGF (show PDGFA Proteins)-R/Stat3 (show STAT3 Proteins) signaling.

FAM3C Protein Profile

Protein Summary

This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells.

Gene names and symbols associated with FAM3C

  • family with sequence similarity 3, member C (fam3c)
  • family with sequence similarity 3, member C (LOC100221204)
  • family with sequence similarity 3, member C (FAM3C)
  • family with sequence similarity 3, member C (Fam3c)
  • D6Wsu176e protein
  • Ilei protein
  • wu:fb99h11 protein
  • wu:fi35h03 protein
  • zgc:55444 protein
  • zgc:77090 protein

Protein level used designations for FAM3C

hypothetical protein LOC549860 , Protein FAM3C , family with sequence similarity 3, member C , protein FAM3C , interleukin-like EMT inducer , predicted osteoblast protein , FAM3C-like protein

GENE ID SPECIES
549860 Xenopus (Silurana) tropicalis
100221204 Taeniopygia guttata
417758 Gallus gallus
463680 Pan troglodytes
10447 Homo sapiens
612336 Canis lupus familiaris
615690 Bos taurus
27999 Mus musculus
312159 Rattus norvegicus
334205 Danio rerio
443905 Xenopus laevis
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