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Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains.
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Human Polyclonal FAM38B Primary Antibody for EIA, WB - ABIN952226
Coste, Mathur, Schmidt, Earley, Ranade, Petrus, Dubin, Patapoutian: Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. in Science (New York, N.Y.) 2010
Show all 2 references for ABIN952226
Human Polyclonal FAM38B Primary Antibody for WB - ABIN2783848
Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003
Transgenic mouse lines lacking Piezo2 in proprioceptive neurons showed severely uncoordinated body movements.
Whole-exome sequencing revealed a novel heterozygous mutation c.4456G>C (p.A1486P) of PIEZO2.
family of mechanically activated channels that counts only two members in human, piezo1 (show PIEZO1 Antibodies) and 2, has emerged recently. [review]
we demonstrate that the mechanosensitivity of human embryonic stem cell-derived touch receptors depends on PIEZO2
this study used exome sequencing to discover that mutations in PIEZO2 cause Gordon syndrome, Marden-Walker syndrome, and distal arthrogryposis type 5.
Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis.
piezo2 sensitization may contribute to PKA- and PKC-mediated mechanical hyperalgesia.
Astrocytes in optic nerve head express multiple mechanosensitive channels, in particular Piezo1 (show PIEZO1 Antibodies) and 2. The expression of putative mechanosensitive channels in these cells may contribute to their responsiveness to traumatic or glaucomatous injury.
mice lacking Piezo2 in both adult sensory neurons and Merkel cells exhibit a profound loss of touch sensation
engineered mice deficient in Piezo2 in the skin, but not in sensory neurons, show that Merkel-cell mechanosensitivity completely depends on Piezo2
data indicate that the Epac1 (show RAPGEF3 Antibodies)-Piezo2 axis has a role in the development of mechanical allodynia during neuropathic pain
overexpression of Piezo1 (show PIEZO1 Antibodies) or Piezo2 induced 2 kinetically distinct mechanically activated (MA) currents; Piezos are expressed in several tissues; propose that Piezos are components of MA cation channels
Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.' The PIEZO2 protein has a role in rapidly adapting mechanically activated (MA) currents in somatosensory neurons (Coste et al., 2010
family with sequence similarity 38, member B
, family with sequence similarity 38, member B2
, protein PIEZO2