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Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. Additionally we are shipping FAM84A Antibodies (32) and FAM84A Proteins (6) and many more products for this protein.
up-regulation of FAM84A may play a critical role in progression of colon cancer
Nse1 RING-like motif is a protein-protein interaction domain required for Smc5-Smc6 holocomplex integrity and recruitment to, or retention at, DNA lesions
FAM84A is up-regulated by CAR during the development of liver tumors.
Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). Has in vitro ubiquitin ligase activity in presence of NDNL2. Is involved in positive regulation of response to DNA damage stimulus.
family with sequence similarity 84, member A
, protein FAM84A
, neurologic sensory protein 1
, neurological/sensory 1
, non-structural maintenance of chromosomes element 1 homolog